Lu Juane, Wu Hao, Wu Shengbo, Wang Shengli, Fan Hongfei, Ruan Haihua, Qiao Jianjun, Caiyin Qinggele, Wen Mingzhang
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Zhejiang Research Institute of Tianjin University (Shaoxing), Shaoxing 312300, China; School of Life Sciences, Tianjin University, Tianjin 300072, China.
Microbiol Res. 2025 Mar;292:128013. doi: 10.1016/j.micres.2024.128013. Epub 2024 Dec 12.
Salmonella is a foodborne pathogen that predominantly resides in the intestinal tract of humans and animals. Infections caused by Salmonella can lead to various illnesses, including gastroenteritis, bacteremia, septicemia, and focal infections, with severe cases potentially resulting in host mortality. The mechanisms by which Salmonella invades host cells and disseminates throughout the body are partly understood, but there are still many scientific questions to be solved. This review aims to synthesize existing research on the interactions between Salmonella and hosts, detailing a comprehensive infection mechanism from adhesion and invasion to intracellular propagation and systemic spread. Overuse of antibiotics contributes to the emergence of drug-resistant Salmonella strains. An in-depth analysis of the mechanism of Salmonella infection will provide a theoretical basis for the development of novel Salmonella control strategies. These innovative control strategies include antibiotic adjuvants, small molecules, phages, attenuated vaccines, and probiotic therapies, which show huge potential in controlling Salmonella infection.
沙门氏菌是一种食源性病原体，主要存在于人和动物的肠道中。沙门氏菌引起的感染可导致各种疾病，包括肠胃炎、菌血症、败血症和局部感染，严重病例可能导致宿主死亡。沙门氏菌侵入宿主细胞并在全身传播的机制已部分为人所知，但仍有许多科学问题有待解决。本综述旨在综合现有的关于沙门氏菌与宿主相互作用的研究，详细阐述从粘附、侵入到细胞内繁殖和全身扩散的全面感染机制。抗生素的过度使用导致了耐药沙门氏菌菌株的出现。深入分析沙门氏菌感染机制将为开发新型沙门氏菌控制策略提供理论基础。这些创新的控制策略包括抗生素佐剂、小分子、噬菌体、减毒疫苗和益生菌疗法，它们在控制沙门氏菌感染方面显示出巨大潜力。
