Iqbal Faiza, Siva N, Shenoy Padmaja A, Lewis Leslie Edward S, Purkayastha Jayashree, Eshwara Vandana Kalwaje
Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India,
Department of Child Health Nursing, Manipal College of Nursing, Manipal Academy of Higher Education (MAHE), Manipal, India.
Neonatology. 2025;122(2):151-160. doi: 10.1159/000542335. Epub 2024 Dec 13.
Gut pathogen colonization, where pathogens disrupt the normal gut microbiota, has been implicated in the development of bloodstream infections (BSIs). This study investigates the association between gut pathogen colonization and BSI, hypothesizing that species causing BSI primarily originated from gut.
A prospective cohort study was conducted in the neonatal intensive care unit (NICU) of tertiary care hospital in Karnataka, India, from January 2021 to September 2023. Inborn preterm infants were enrolled. The study population was divided into two groups: group A (neonates without sepsis) and group B (neonates with sepsis). Demographic details and blood culture results were collected. Stool samples were taken on day 4 and day 14 for group A, and on day 4 and the day of sepsis diagnosis for group B.
Group B had a lower mean birthweight (1,649.6 ± 652.1 g) compared to group A (1,757 ± 656 g). Klebsiella pneumoniae was the most common pathogen causing BSIs (44.1%). The analysis revealed a high abundance of potential pathogens in the gut microbiome of group B neonates, with a concurrent decrease in beneficial gut flora.
This study provides strong evidence for the association between gut pathogen colonization and BSI development in preterm neonates in NICUs. Gut microbiota modulation may serve as preventive strategy against BSIs, emphasizing the need for further research in this area to improve outcomes in vulnerable population.
Gut pathogen colonization, where pathogens disrupt the normal gut microbiota, has been implicated in the development of bloodstream infections (BSIs). This study investigates the association between gut pathogen colonization and BSI, hypothesizing that species causing BSI primarily originated from gut.
A prospective cohort study was conducted in the neonatal intensive care unit (NICU) of tertiary care hospital in Karnataka, India, from January 2021 to September 2023. Inborn preterm infants were enrolled. The study population was divided into two groups: group A (neonates without sepsis) and group B (neonates with sepsis). Demographic details and blood culture results were collected. Stool samples were taken on day 4 and day 14 for group A, and on day 4 and the day of sepsis diagnosis for group B.
Group B had a lower mean birthweight (1,649.6 ± 652.1 g) compared to group A (1,757 ± 656 g). Klebsiella pneumoniae was the most common pathogen causing BSIs (44.1%). The analysis revealed a high abundance of potential pathogens in the gut microbiome of group B neonates, with a concurrent decrease in beneficial gut flora.
This study provides strong evidence for the association between gut pathogen colonization and BSI development in preterm neonates in NICUs. Gut microbiota modulation may serve as preventive strategy against BSIs, emphasizing the need for further research in this area to improve outcomes in vulnerable population.
肠道病原体定植是指病原体破坏正常的肠道微生物群，这与血流感染（BSIs）的发生有关。本研究调查肠道病原体定植与BSIs之间的关联，假设引起BSIs的病原体主要源自肠道。
2021年1月至2023年9月，在印度卡纳塔克邦一家三级护理医院的新生儿重症监护病房（NICU）进行了一项前瞻性队列研究。纳入了早产的新生儿。研究人群分为两组：A组（无败血症的新生儿）和B组（有败血症的新生儿）。收集了人口统计学细节和血培养结果。A组在第4天和第14天采集粪便样本，B组在第4天和败血症诊断当天采集粪便样本。
与A组（1757±656g）相比，B组的平均出生体重较低（1649.6±652.1g）。肺炎克雷伯菌是引起BSIs最常见的病原体（44.1%）。分析显示，B组新生儿的肠道微生物群中潜在病原体的丰度较高，同时有益肠道菌群减少。
本研究为NICU中早产新生儿肠道病原体定植与BSIs发生之间的关联提供了有力证据。调节肠道微生物群可能作为预防BSIs的策略，强调在该领域需要进一步研究以改善弱势群体的预后。
肠道病原体定植是指病原体破坏正常的肠道微生物群，这与血流感染（BSIs）的发生有关。本研究调查肠道病原体定植与BSIs之间的关联，假设引起BSIs的病原体主要源自肠道。
2021年1月至2023年9月，在印度卡纳塔克邦一家三级护理医院的新生儿重症监护病房（NICU）进行了一项前瞻性队列研究。纳入了早产的新生儿。研究人群分为两组：A组（无败血症的新生儿）和B组（有败血症的新生儿）。收集了人口统计学细节和血培养结果。A组在第4天和第14天采集粪便样本，B组在第4天和败血症诊断当天采集粪便样本。
与A组（1757±656g）相比，B组的平均出生体重较低（1649.6±652.1g）。肺炎克雷伯菌是引起BSIs最常见的病原体（44.1%）。分析显示，B组新生儿的肠道微生物群中潜在病原体的丰度较高，同时有益肠道菌群减少。
本研究为NICU中早产新生儿肠道病原体定植与BSIs发生之间的关联提供了有力证据。调节肠道微生物群可能作为预防BSIs的策略，强调在该领域需要进一步研究以改善弱势群体的预后。
