Fukuzawa Satoshi, Yamagata Kenji, Takasaki Ryo, Uchida Fumihiko, Ishibashi-Kanno Naomi, Bukawa Hiroki
Oral and Maxillofacial Surgery, Department of Clinical Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Oral and Maxillofacial Surgery, Department of Clinical Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
J Stomatol Oral Maxillofac Surg. 2025 Jun;126(3S):102201. doi: 10.1016/j.jormas.2024.102201. Epub 2024 Dec 14.
To clarify the effects of preoperative nutritional evaluation on the prognosis of patients with tongue squamous cell carcinoma.
This retrospective cohort study involves 126 consecutive patients who underwent radical surgery as their initial treatment and received treatment for >3 years. The markers considered in this study are GGT (γ-GTP), CAR (C-reactive protein (CRP)-to-Alb Ratio), GLR (GGT-to-Lymphocytes Ratio), GPR (GGT-to-Platelet ratio), GNR (GGT-to-Neutrophil ratio), NLR (Neutrophil-to-Lymphocyte ratio), PLR (platelet-to-lymphocytes ratio), OPNI (Onodera`s prognostic nutritional index), PINI (Prognostic Immune and Nutritional Index) and Albumin (Alb). Each marker was calculated from blood test results up to one month before the initial surgery to assess overall survival (OS) and disease-free survival (DFS).
Univariate analysis of OS identified the depth of invasion (DOI P = 0.004), stage classification (P < 0.001), Body mass index (BMI) (P = 0.007), OPNI (P = 0.005), prognostic inflammatory and nutritional indices (PINI, P = 0.011), and albumin (Alb) (P = 0.006) as significant predictors. Cox regression analysis revealed significant differences in BMI, pathological grade, and OPNI. The OPNI cut-off value was 51.05, indicating its effectiveness in predicting tongue cancer prognosis. With regard to DFS, only BMI showed a significant difference, with no notable difference among other markers.
The OPNI may be a useful prognostic factor for tongue cancer.
阐明术前营养评估对舌鳞状细胞癌患者预后的影响。
这项回顾性队列研究纳入了126例连续接受根治性手术作为初始治疗且治疗时间超过3年的患者。本研究中考虑的指标包括γ-谷氨酰转肽酶（GGT）、C反应蛋白与白蛋白比值（CAR）、GGT与淋巴细胞比值（GLR）、GGT与血小板比值（GPR）、GGT与中性粒细胞比值（GNR）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、小野寺预后营养指数（OPNI）、预后免疫和营养指数（PINI）以及白蛋白（Alb）。每个指标均根据初次手术前1个月内的血液检测结果计算得出，以评估总生存期（OS）和无病生存期（DFS）。
OS的单因素分析确定浸润深度（DOI，P = 0.004）、分期分类（P < 0.001）、体重指数（BMI，P = 0.007）、OPNI（P = 0.005）、预后炎症和营养指数（PINI，P = 0.011）以及白蛋白（Alb，P = 0.006）为显著预测因素。Cox回归分析显示BMI、病理分级和OPNI存在显著差异。OPNI的临界值为51.05，表明其在预测舌癌预后方面的有效性。关于DFS，只有BMI显示出显著差异，其他指标之间无显著差异。
OPNI可能是舌癌的一个有用的预后因素。
