Cankaya Seyda, Ayyildiz Behcet, Sayman Dila, Duran Umutcan, Ucak Dogukan, Karaca Ramazan, Ayyildiz Sevilay, Oktem Ece Ozdemir, Lakadamyalı Hatice, Sayman Ceyhun, Ozsimsek Ahmet, Yalçınkaya Ali, Hanoglu Lutfu, Velioglu Halil Aziz, Yulug Burak
Department of Neurology and Neuroscience, Alanya Alaaddin Keykubat University, 07400, Antalya, Turkiye.
Anatomy PhD Programme, Graduate School of Health Sciences, Kocaeli University, 41380, Kocaeli, Turkiye.
Neuroimage. 2025 Jan;305:120961. doi: 10.1016/j.neuroimage.2024.120961. Epub 2024 Dec 13.
The etiology of cognitive decline linked to migraine remains unclear, with a growing recurrence rate and potential increased dementia risk among sufferers. Cognitive dysfunction has recently gained attention as a significant problem among migraine sufferers that can be related to alterations in hippocampal function and structure. This study explores hippocampal subfield connectivity and volume changes in migraine patients. We recruited 90 individuals from Alanya University's Neurology Department, including 49 migraine patients and 41 controls, for functional and anatomical imaging. Using the CONN toolbox and FreeSurfer, we assessed functional connectivity and subfield volumes, respectively. Montreal Cognitive Assessment (MOCA) was used to assess cognition in the entire sample. As a result, migraine patients exhibited significantly lower MOCA scores compared to controls (p<.001). Also, we found significant differences in hippocampal subfields between migraine patients and control groups in terms of functional connectivity after adjusting for years of education; here we showed that the left CA3 showed higher connectivity with right MFG and right occipitolateral cortex. Furthermore, the connectivity of left fimbria with the left temporal lobe and hippocampus and the connectivity of the right hippocampal-tail with right insula, heschl's gyrus, and frontorbital cortex were lower in the migraineurs. Additionally, volumes of specific hippocampal subfields were significantly lower in the migraineurs (whole hippocampus p = 0.004, whole hippocampus head p = 0.003, right CA1 head p = 0.006, and right HATA p = 0.005) compared to controls. In conclusion, these findings indicate that migraine-associated cognitive impairment involves significant functional and structural brain changes, particularly in the hippocampus, which may heighten dementia risk. This pioneering study unveils critical hippocampal alterations linked to cognitive function in migraine sufferers, underscoring the potential for these changes to impact dementia development.
与偏头痛相关的认知衰退的病因仍不明确，患者的复发率不断上升，患痴呆症的风险可能也会增加。认知功能障碍最近作为偏头痛患者中的一个重大问题受到关注，这可能与海马体功能和结构的改变有关。本研究探讨偏头痛患者海马体亚区的连通性和体积变化。我们从阿拉尼亚大学神经科招募了90名个体，其中包括49名偏头痛患者和41名对照者，进行功能和解剖成像。我们分别使用CONN工具箱和FreeSurfer评估功能连通性和亚区体积。使用蒙特利尔认知评估量表（MOCA）对整个样本的认知能力进行评估。结果显示，与对照组相比，偏头痛患者的MOCA评分显著更低（p<0.001）。此外，在对受教育年限进行校正后，我们发现偏头痛患者和对照组在海马体亚区的功能连通性方面存在显著差异；我们发现左侧CA3与右侧额中回和右侧枕颞外侧皮质的连通性更高。此外，偏头痛患者左侧穹窿与左侧颞叶和海马体的连通性以及右侧海马尾部与右侧岛叶、颞横回和额眶皮质的连通性较低。此外，与对照组相比，偏头痛患者特定海马体亚区的体积显著更小（全海马体p = 0.004，海马体头部整体p = 0.003，右侧CA1头部p = 0.006，右侧HATA p = 0.005）。总之，这些发现表明，与偏头痛相关的认知障碍涉及大脑显著的功能和结构变化，尤其是在海马体，这可能会增加患痴呆症的风险。这项开创性研究揭示了与偏头痛患者认知功能相关的关键海马体改变，强调了这些变化对痴呆症发展产生影响的可能性。
