Meyer Thomas D, Ibrahim Maya, Vale Lauren N, Soares Jair C
Louis A. Faillace Department of Psychiatry & Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, 1941 East Rd, Houston, TX 77054, USA.
J Affect Disord. 2025 Mar 15;373:505-511. doi: 10.1016/j.jad.2024.12.044. Epub 2024 Dec 13.
Psychedelic substances such as psilocybin have recently gained attention for their potential therapeutic benefits in treating depression and other mental health problems. However, individuals with bipolar disorder (BD) have been excluded from most clinical trials due to concerns about manic switches or psychosis. This study aimed to systematically examine the effects of recreational psychedelic use in individuals with BD. Using the Timeline Followback (TLFB) method, we assessed mood symptoms, substance use, and other mental health-related variables in the month before and three months following participants' most recent psychedelic experience. Results showed a significant reduction in depressive symptoms and cannabis use, an increase in the number of days without mental health symptoms, and an increase in the number of days with hallucinogen use. Importantly, no significant changes in (hypo)manic, psychotic, or anxiety symptoms were observed. These findings suggest that psychedelics may hold potential as a safe and effective treatment for BD, though further research, including randomized controlled trials, is needed.
诸如裸盖菇素之类的致幻物质最近因其在治疗抑郁症和其他心理健康问题方面的潜在治疗益处而受到关注。然而，由于担心躁狂发作或精神病，双相情感障碍（BD）患者被排除在大多数临床试验之外。本研究旨在系统地研究娱乐性使用致幻剂对BD患者的影响。我们使用时间线追溯法（TLFB），评估了参与者最近一次致幻体验前一个月和之后三个月的情绪症状、物质使用情况以及其他与心理健康相关的变量。结果显示，抑郁症状和大麻使用显著减少，无心理健康症状的天数增加，使用致幻剂的天数增加。重要的是，未观察到（轻）躁狂、精神病或焦虑症状有显著变化。这些发现表明，致幻剂可能具有作为BD安全有效治疗方法的潜力，不过还需要进一步的研究，包括随机对照试验。
