Heller Alexis, Collins Victoria
Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Int J Surg Pathol. 2025 Aug;33(5):1230-1233. doi: 10.1177/10668969241300532. Epub 2024 Dec 15.
Mammary-like anogenital glands are considered a normal constituent of the anogenital area. These glands can have epithelial components with eccrine or apocrine features. They often undergo transformation into mammary-like lesions, including lactational changes that occur during pregnancy and the breastfeeding period. When they form mass lesions they are referred to as lactating adenomas. Their appearance can clinically be mistaken for other more common benign and malignant entities in the vulva. We describe a vulvar lesion in a 26-year-old woman. The lesion was excised and determined by histologic examination to be a benign lactating adenoma. Subsequent immunohistochemistry was performed. The epithelial cells were positive for GATA3 and estrogen receptor while negative for PAX8, supporting mammary-like differentiation. The myoepithelial markers p63 and calponin were positive at the periphery of the ducts, supporting the benign nature of this lesion.
乳腺样的肛门生殖器腺被认为是肛门生殖器区域的正常组成部分。这些腺体可具有具有外分泌或顶分泌特征的上皮成分。它们常发生转化为乳腺样病变，包括妊娠和哺乳期出现的泌乳变化。当它们形成肿块病变时，被称为泌乳性腺瘤。其外观在临床上可能被误诊为外阴其他更常见的良性和恶性病变。我们描述了一名26岁女性的外阴病变。该病变被切除，经组织学检查确定为良性泌乳性腺瘤。随后进行了免疫组织化学检查。上皮细胞GATA3和雌激素受体阳性，而PAX8阴性，支持乳腺样分化。肌上皮标志物p63和钙调蛋白在导管周围呈阳性，支持该病变的良性性质。
