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诊断中的人工智能:使用基于手机的读取系统提高尿液检测准确性。

Artificial Intelligence in Diagnostics: Enhancing Urine Test Accuracy Using a Mobile Phone-Based Reading System.

作者信息

Kim Hyun Jin, Kim Manmyung, Zhang Hyunjae, Kim Hae Ri, Jeon Jae Wan, Seo Yuri, Choi Qute

机构信息

Department of Laboratory Medicine, Chungnam National University School of Medicine, Daejeon, Korea.

Department of Laboratory Medicine, Chungnam National University Sejong Hospital, Sejong, Korea.

出版信息

Ann Lab Med. 2025 Mar 1;45(2):178-184. doi: 10.3343/alm.2024.0304. Epub 2024 Dec 16.

DOI:10.3343/alm.2024.0304
PMID:39676422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11788702/
Abstract

BACKGROUND

Urinalysis, an essential diagnostic tool, faces challenges in terms of standardization and accuracy. The use of artificial intelligence (AI) with mobile technology can potentially solve these challenges. Therefore, we investigated the effectiveness and accuracy of an AI-based program in automatically interpreting urine test strips using mobile phone cameras, an approach that may revolutionize point-of-care testing.

METHODS

We developed novel urine test strips and an AI algorithm for image capture. Sample images from the Chungnam National University Sejong Hospital were collected to train a k-nearest neighbor classification algorithm to read the strips. A mobile application was developed for image capturing and processing. We assessed the accuracy, sensitivity, specificity, and ROC area under the curve for 10 parameters.

RESULTS

In total, 2,612 urine test strip images were collected. The AI algorithm demonstrated 98.7% accuracy in detecting urinary nitrite and 97.3% accuracy in detecting urinary glucose. The sensitivity and specificity were high for most parameters. However, this system could not reliably determine the specific gravity. The optimal time for capturing the test strip results was 75 secs after dipping.

CONCLUSIONS

The AI-based program accurately interpreted urine test strips using smartphone cameras, offering an accessible and efficient method for urinalysis. This system can be used for immediate analysis and remote testing. Further research is warranted to refine test parameters such as specific gravity to enhance accuracy and reliability.

摘要

背景

尿液分析作为一种重要的诊断工具,在标准化和准确性方面面临挑战。人工智能(AI)与移动技术的结合有可能解决这些挑战。因此,我们研究了一种基于AI的程序使用手机摄像头自动解读尿试纸条的有效性和准确性,这种方法可能会彻底改变即时检验。

方法

我们开发了新型尿试纸条和用于图像采集的AI算法。收集了忠南国立大学世宗医院的样本图像,以训练k近邻分类算法来读取试纸条。开发了一个用于图像采集和处理的移动应用程序。我们评估了10个参数的准确性、敏感性、特异性和曲线下ROC面积。

结果

总共收集了2612张尿试纸条图像。AI算法检测尿亚硝酸盐的准确率为98.7%,检测尿葡萄糖的准确率为97.3%。大多数参数的敏感性和特异性都很高。然而,该系统无法可靠地确定比重。读取试纸条结果的最佳时间是浸入后75秒。

结论

基于AI的程序使用智能手机摄像头准确解读尿试纸条,为尿液分析提供了一种便捷高效的方法。该系统可用于即时分析和远程检测。有必要进一步研究优化诸如比重等检测参数,以提高准确性和可靠性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b4/11788702/2ea073bbb27b/alm-45-2-178-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b4/11788702/4300e4341751/alm-45-2-178-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b4/11788702/397f26eeaef6/alm-45-2-178-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b4/11788702/1bf00c4aa86f/alm-45-2-178-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b4/11788702/2ea073bbb27b/alm-45-2-178-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b4/11788702/4300e4341751/alm-45-2-178-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b4/11788702/397f26eeaef6/alm-45-2-178-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b4/11788702/1bf00c4aa86f/alm-45-2-178-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b4/11788702/2ea073bbb27b/alm-45-2-178-f4.jpg

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本文引用的文献

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Clin Chem. 2023 Dec 1;69(12):1348-1360. doi: 10.1093/clinchem/hvad136.
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Artificial Intelligence in Point-of-Care Testing.即时检验中的人工智能。
Ann Lab Med. 2023 Sep 1;43(5):401-407. doi: 10.3343/alm.2023.43.5.401. Epub 2023 Apr 21.
3
Improving the reliability of smartphone-based urine colorimetry using a colour card calibration method.使用色卡校准方法提高基于智能手机的尿液比色法的可靠性。
Digit Health. 2023 Feb 10;9:20552076231154684. doi: 10.1177/20552076231154684. eCollection 2023 Jan-Dec.
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Smartphone-Based Colorimetric Analysis of Urine Test Strips for At-Home Prenatal Care.基于智能手机的尿液检测试纸比色分析用于家庭产前护理。
IEEE J Transl Eng Health Med. 2022 May 30;10:2800109. doi: 10.1109/JTEHM.2022.3179147. eCollection 2022.
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Remote digital urinalysis with smartphone technology as part of remote management of glomerular disease during the SARS-CoV-2 virus pandemic: single-centre experience in 25 patients.在严重急性呼吸综合征冠状病毒2(SARS-CoV-2)病毒大流行期间,将智能手机技术用于远程数字尿液分析作为肾小球疾病远程管理的一部分:25例患者的单中心经验
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Current and emerging trends in point-of-care urinalysis tests.即时检验尿液分析测试的当前及新出现的趋势。
Expert Rev Mol Diagn. 2020 Jan;20(1):69-84. doi: 10.1080/14737159.2020.1699063. Epub 2019 Dec 12.
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Dipstick analysis of urine chemistry: benefits and limitations of dry chemistry-based assays.尿液化学干化学分析试带法:优势与局限性。
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Performance of an artificial intelligence algorithm for reporting urine cytopathology.人工智能算法在尿细胞学报告中的性能。
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