Peng Xin-Chen, Yin Ruoyanran, Luo Li-Ping, Xu Shengqian, Shuai Zongwen
Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People's Republic of China.
J Inflamm Res. 2024 Dec 10;17:10699-10709. doi: 10.2147/JIR.S488605. eCollection 2024.
Rheumatoid factor (RF) titer is known to be correlated to rheumatoid arthritis (RA) activity, but the ideal cut-off titer of RF remains unclear. Here, the relationship between RF titer and RA activity was investigated in order to determine the ideal RF value indicative of the risk of RA activity.
Clinical data from 2044 eligible patients were collected from the First Affiliated Hospital of Anhui Medical University from February 2022 to October 2023. A restricted cubic spline (RCS) model was used to evaluate the relationship between RF titer and RA activity.
Data from a total of 2044 patients with RA were collected and analyzed. Multivariate logistic regression analysis revealed that higher RF levels were significant predictors of the risk of RA activity calculated according to the disease activity score 28 (DAS28)-erythrocyte sedimentation rate (ESR) (OR = 2.020, 95% CI = 1.457-2.801, P < 0.001) and DAS28-C reactive protein (CRP) (OR = 1.526, 95% CI = 1.092-2.131, P = 0.013), after the results were adjusted for potential covariates. The relationship between log2RF and the risk of RA activity was non‑linear in the RCS model (P < 0.05). The cutoff value of RF titers for determining the risk of RA activity was 65.80 IU/mL. When RF exceeded the cutoff value, the risk of RA activity based on DAS28-ESR increased by 99.2% and the risk of RA activity based on DAS28-CRP increased by 62.8% (P < 0.001).
The risk of RA activity increased non-linearly with the continuous change in RF titer.
类风湿因子（RF）滴度与类风湿关节炎（RA）活动度相关，但RF的理想临界滴度仍不明确。在此，研究了RF滴度与RA活动度之间的关系，以确定指示RA活动风险的理想RF值。
收集2022年2月至2023年10月安徽医科大学第一附属医院2044例符合条件患者的临床资料。使用受限立方样条（RCS）模型评估RF滴度与RA活动度之间的关系。
共收集并分析了2044例RA患者的数据。多因素logistic回归分析显示，在对潜在协变量进行校正后，较高的RF水平是根据疾病活动评分28（DAS28）-红细胞沉降率（ESR）计算的RA活动风险的显著预测因素（OR = 2.020，95%CI = 1.457 - 2.801，P < 0.001）以及DAS28 - C反应蛋白（CRP）（OR = 1.526，95%CI = 1.092 - 2.131，P = 0.013）。在RCS模型中，log2RF与RA活动风险之间的关系呈非线性（P < 0.05）。确定RA活动风险的RF滴度临界值为65.80 IU/mL。当RF超过临界值时，基于DAS28 - ESR的RA活动风险增加99.2%，基于DAS28 - CRP的RA活动风险增加62.8%（P < 0.001）。
RA活动风险随RF滴度的持续变化呈非线性增加。
