Pedersen Maria Weinkouff, Oksjoki Riina, Møller Jacob Eifer, Gundlund Anna, Fosbøl Emil, Nielsen Dorte Guldbrand, Køber Lars, Andersen Mikkel Porsborg, Torp-Pedersen Christian, Søgaard Peter, Andersen Niels Holmark, Kragholm Kristian
Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark.
Tex Heart Inst J. 2024 Dec 12;51(2):e238366. doi: 10.14503/THIJ-23-8366. eCollection 2024 Jul-Dec.
Little is known about long-term outcomes beyond survival following acute aortic dissection. The aim of this research was to evaluate rates of home care initiation and nursing home admission during the first year after discharge and to assess factors associated with these needs.
All patients in Denmark with a first-time diagnosis of acute aortic dissection type A or B between 2006 and 2015 were identified using national registries. Patients discharged alive without nursing home or home care use before aortic dissection were included, along with age-matched and sex-matched population controls without aortic dissection (at a ratio of 1:5). Cause-specific multivariable Cox regression was used to derive adjusted hazard ratios.
The study population comprised 1093 patients and 5465 control individuals with a median (IQR) age of 64 (55-71) years; 70.6% were men. During their hospital stay, 2.7% of patients were registered with a first-time diagnosis of stroke, 7.1% with heart failure, and 2.2% with acute kidney failure; 5.9% of patients needed first-time dialysis. During the first year after discharge, 0.8% of patients who had had aortic dissection were admitted to a nursing home, 7.8% started home care, and 5.9% died. Among controls, these rates were 0.2%, 1.2%, and 1.2%, respectively. Patients who had had aortic dissection had significantly increased risk of initiating home care (hazard ratio, 7.47 [95% CI, 5.38-18.37]; < .001) and of being admitted to a nursing home (hazard ratio, 4.28 [95% CI, 1.73-10.59]; = .001). Initiation of home care and nursing home admission were related to advanced age, female sex, preexisting comorbidities, in-hospital complications, and conservative management of type A aortic dissection.
Only a small proportion of patients who survived an aortic dissection needed home care or nursing home admission after hospital discharge.
关于急性主动脉夹层分离后生存期以外的长期预后知之甚少。本研究的目的是评估出院后第一年开始接受家庭护理和入住疗养院的比例,并评估与这些需求相关的因素。
利用国家登记系统确定2006年至2015年间丹麦所有首次诊断为A型或B型急性主动脉夹层分离的患者。纳入在主动脉夹层分离前未使用疗养院或家庭护理且存活出院的患者,以及年龄和性别匹配的无主动脉夹层的人群对照(比例为1:5)。采用特定病因多变量Cox回归得出调整后的风险比。
研究人群包括1093例患者和5465例对照个体,中位(IQR)年龄为64(55 - 71)岁;70.6%为男性。在住院期间,2.7%的患者首次诊断为中风,7.1%为心力衰竭,2.2%为急性肾衰竭;5.9%的患者需要首次透析。出院后第一年,主动脉夹层分离患者中有0.8%入住疗养院,7.8%开始接受家庭护理,5.9%死亡。对照组的这些比例分别为0.2%、1.2%和1.2%。主动脉夹层分离患者开始接受家庭护理(风险比,7.47 [95% CI,5.38 - 18.37];P <.001)和入住疗养院(风险比,4.28 [95% CI,1.73 - 10.59];P =.001)的风险显著增加。开始接受家庭护理和入住疗养院与高龄、女性、既往合并症、住院并发症以及A型主动脉夹层分离的保守治疗有关。
主动脉夹层分离存活患者中只有一小部分在出院后需要家庭护理或入住疗养院。