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Acute toxicity of folic acid in mice.

作者信息

Parchure M, Ambaye R Y, Lalitha V S, Gokhale S V

出版信息

Experientia. 1985 Jan 15;41(1):72-3. doi: 10.1007/BF02005881.

Abstract

The toxicity of folic acid (PGA) was studied in different inbred strains of mice. LD50 values of PGA by the i.p. route showed a unique toxicity pattern. In some strains, convulsions, ataxia and weakness were observed. Histopathological study in strains S/RVCri, BDF1, DBA/2 and DBA/2fNCri showed acute renal tubular necrosis.

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