叶酸对小鼠的急性毒性
Acute toxicity of folic acid in mice.
作者信息
Parchure M, Ambaye R Y, Lalitha V S, Gokhale S V
出版信息
Experientia. 1985 Jan 15;41(1):72-3. doi: 10.1007/BF02005881.
PMID:3967741
Abstract
The toxicity of folic acid (PGA) was studied in different inbred strains of mice. LD50 values of PGA by the i.p. route showed a unique toxicity pattern. In some strains, convulsions, ataxia and weakness were observed. Histopathological study in strains S/RVCri, BDF1, DBA/2 and DBA/2fNCri showed acute renal tubular necrosis.
摘要
在不同近交系小鼠中研究了叶酸（PGA）的毒性。经腹腔注射途径给予PGA的半数致死量（LD50）值呈现出独特的毒性模式。在某些品系中，观察到惊厥、共济失调和虚弱。对S/RVCri、BDF1、DBA/2和DBA/2fNCri品系的组织病理学研究显示有急性肾小管坏死。
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