Chopra R K, Sharma M, Nath R
Exp Cell Biol. 1985;53(1):19-23. doi: 10.1159/000163291.
The immunomodulatory effects of cadmium, an environmental pollutant, were assessed in male rhesus monkeys orally exposed to 5 mg cadmium/kg body weight for a period of 4 months. A lymphocyte transformation test was carried out in peripheral blood lymphocytes using different concentrations of phytohemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM). Cadmium exposure of monkeys resulted in a statistically nonsignificant increase in [3H]thymidine incorporation in PHA- and Con-A-stimulated lymphocytes. However, there was a nonsignificant decrease in [3H]thymidine incorporation in PWM-stimulated lymphocytes. These results suggest that cadmium may not have immunosuppressive effects in primates which are phylogenetically close to man.
对雄性恒河猴进行了一项研究，评估环境污染物镉的免疫调节作用。这些猴子经口暴露于5毫克镉/千克体重，持续4个月。使用不同浓度的植物血凝素（PHA）、刀豆蛋白A（Con A）和商陆有丝分裂原（PWM）对外周血淋巴细胞进行淋巴细胞转化试验。镉暴露使猴子在PHA和Con A刺激的淋巴细胞中[3H]胸腺嘧啶核苷掺入量有统计学上无显著意义的增加。然而，在PWM刺激的淋巴细胞中，[3H]胸腺嘧啶核苷掺入量有不显著的减少。这些结果表明，镉在系统发育上与人类接近的灵长类动物中可能没有免疫抑制作用。
