Karadağ Mehmet, Turgut Fatma Subaşı, Çiftçi Zehra, Hangül Zehra, Taysi Seyithan
Department of Child and Adolescent Psychiatry, Faculty of Medicine, Gaziantep University, Gaziantep, Türkiye.
Department of Child and Adolescent Psychiatry, Faculty of Medicine, Dicle University, Diyarbakır, Türkiye.
Noro Psikiyatr Ars. 2024 Nov 28;61(4):306-312. doi: 10.29399/npa.28650. eCollection 2024.
USP9X has been associated with neurodevelopmental disorders due to its role in synaptic development and neural function. This study aimed to compare USP9X and TGF-β levels in children with autism and healthy controls, and explore their relationship with autism severity.
Serum USP9X and TGF-β levels were measured in 41 healthy control children (aged 3-12 years) and 41 children with autism.
Our study revealed a significant increase in USP9X levels (p=0.001) among children with autism compared to controls. However, TGF-β levels showed no significant difference between the two groups. Furthermore, we observed a positive correlation between difficulty in making eye contact subscale and blood levels of both USP9X and TGF-β.
This study is the first to compare serum USP9X levels in children with autism to healthy controls. Our findings suggest USP9X's potential role in autism development, emphasizing the need for further research on its involvement in neurodevelopmental processes.
由于USP9X在突触发育和神经功能中发挥作用，它已被认为与神经发育障碍有关。本研究旨在比较自闭症儿童和健康对照儿童中USP9X和转化生长因子-β（TGF-β）的水平，并探讨它们与自闭症严重程度的关系。
对41名健康对照儿童（3至12岁）和41名自闭症儿童测量血清USP9X和TGF-β水平。
我们的研究显示，与对照组相比，自闭症儿童的USP9X水平显著升高（p = 0.001）。然而，两组之间的TGF-β水平没有显著差异。此外，我们观察到眼神接触困难分量表与USP9X和TGF-β的血液水平之间存在正相关。
本研究首次比较了自闭症儿童与健康对照儿童的血清USP9X水平。我们的研究结果表明USP9X在自闭症发展中可能发挥的作用，强调需要进一步研究其在神经发育过程中的参与情况。
