Editorial: Pancreatic beta-cell dedifferentiation.
作者信息
Tang Xiaoqing, Kuo Taiyi, Wei Zong
机构信息
Department of Biological Sciences, Michigan Technological University, Houghton, MI, United States.
Department of Neurobiology, Physiology, and Behavior, University of California at Davis, Davis, CA, United States.
出版信息
Front Endocrinol (Lausanne). 2024 Nov 29;15:1524001. doi: 10.3389/fendo.2024.1524001. eCollection 2024.
Abstract
摘要
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Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D.人类胰岛发生的单细胞转录组学定义了 T2D 中β细胞去分化的分子基础。
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Pdx1 maintains β cell identity and function by repressing an α cell program.胰腺十二指肠同源盒基因1通过抑制α细胞程序来维持β细胞的特性和功能。
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Identification of genes selectively disallowed in the pancreatic islet.鉴定胰岛中选择性缺失的基因。
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