Gong Hao, Jiang Yuhan, Jiang Tianyuchen, Yang Yi, Wu Zhujuan, Xiao Jie, Su Anping
Division of Thyroid & Parathyroid Surgery, Department of General Surgery, West China Hospital Sichuan University, Chengdu, China.
Department of Otorhinolaryngology-Head & Neck Surgery, West China Hospital Sichuan University, Chengdu, China.
Gland Surg. 2024 Nov 30;13(11):2078-2097. doi: 10.21037/gs-24-317. Epub 2024 Nov 26.
Primary thyroid lymphoma (PTL) is a rare malignancy of the thyroid gland that poses significant clinical challenges due to its rarity and the varied therapeutic approaches it demands. Although recent years have seen an increasing focus on PTL, there is a notable lack of bibliometric analyses that consolidate the evolving research within this field. This study aims to analyze and highlight the research hotspots and trend changes in PTL, elucidating their clinical implications and guiding future research.
We conducted a systematic bibliometric analysis of literature on PTL published from 2000 to 2023. This involved a structured search in the Web of Science Core Collection, using medical subject headings (MeSH) from the MeSH database to refine and eliminate duplicates, forming a precise search formula. Relevant publications were limited to English-language articles and reviews, which were then processed and analyzed using CiteSpace (6.2.R4) for visualization. The analysis, performed with CiteSpace software, facilitated the visualization of trends and hotspots in PTL research by mapping citation networks and identifying key themes and influential works.
Our search yielded 281 literature records on PTL, demonstrating a curvilinear upward trend in publications over the years. The majority of publications originated from China, with the most influential contributions coming from the United States. Hirokawa Mitsuyoshi and Derringer Ga were identified as the most prolific and most co-cited authors, respectively. Keyword and co-citation analyses indicated a growing interest in clinicopathological features, treatment modalities, survival outcomes of different PTL subtypes, risk factors, complementary diagnostic techniques, and immunotherapeutic approaches.
This bibliometric analysis underscores the significant clinical relevance of understanding the pathologies, diagnostic challenges, and treatment strategies for PTL. The identified research hotspots, particularly in pathological typing, diagnosis and treatment modalities, gene expression profiles, targeted therapies, clinical trials, and survival rates, highlight critical areas requiring continued research focus. These insights have pivotal implications for improving patient outcomes and advancing the clinical management of PTL.
原发性甲状腺淋巴瘤（PTL）是一种罕见的甲状腺恶性肿瘤，因其罕见性以及所需的多种治疗方法而带来重大临床挑战。尽管近年来对PTL的关注日益增加，但明显缺乏整合该领域不断发展的研究的文献计量分析。本研究旨在分析并突出PTL的研究热点和趋势变化，阐明其临床意义并指导未来研究。
我们对2000年至2023年发表的关于PTL的文献进行了系统的文献计量分析。这包括在科学网核心合集中进行结构化搜索，使用医学主题词表（MeSH）数据库中的医学主题词来细化和消除重复项，形成精确的搜索公式。相关出版物限于英文文章和综述，然后使用CiteSpace（6.2.R4）进行处理和分析以进行可视化。使用CiteSpace软件进行的分析通过绘制引文网络并识别关键主题和有影响力的作品，促进了PTL研究趋势和热点的可视化。
我们的搜索产生了281条关于PTL的文献记录，表明这些年来出版物呈曲线上升趋势。大多数出版物来自中国，最具影响力的贡献来自美国。广川光义（Hirokawa Mitsuyoshi）和德林杰·加（Derringer Ga）分别被确定为发文量最多和被引频次最高的作者。关键词和共被引分析表明，人们对不同PTL亚型的临床病理特征、治疗方式、生存结果、危险因素、辅助诊断技术和免疫治疗方法的兴趣日益增加。
这项文献计量分析强调了了解PTL的病理学、诊断挑战和治疗策略的重大临床相关性。确定的研究热点，特别是在病理分型、诊断和治疗方式、基因表达谱、靶向治疗、临床试验和生存率方面，突出了需要持续研究关注的关键领域。这些见解对改善患者预后和推进PTL的临床管理具有关键意义。
