Wang Shuqin, Peng Yixin, Jiang Cailing, Lin Zicong, Infante-Cossio Pedro, Li Jun
Department of Oral and Maxillofacial Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Shenzhen Nanshan Medical Group Headquarter, Shenzhen, China.
Gland Surg. 2024 Nov 30;13(11):2198-2205. doi: 10.21037/gs-24-422. Epub 2024 Nov 26.
Secretory carcinoma (SC) represents a relatively new and less recognized subtype of salivary gland cancer among clinicians. The objective of our study was to shed light on this rare entity by providing an in-depth analysis of the clinical presentation, pathological characteristics, and treatment outcomes of five patients diagnosed with SC. We also sought to contribute to the understanding of the diagnostic criteria and prognostic factors associated with SC.
The patients, treated at Guangdong Provincial People's Hospital, were aged between 33 and 40 years, with an average age of 33 years. Notably, none of the patients reported pain or noticed a mass initially; however, the mass became progressively larger over time. Diagnostic imaging, such as magnetic resonance imaging (MRI), led to the classification of four cases as benign and one as a low-grade malignancy. We meticulously documented the diagnostic and treatment journey of these patients, including the clinical data, histopathological findings, and subsequent treatment responses.
Our findings suggest that SC is associated with a favorable prognosis. Nevertheless, the clinical presentation of SC lacks distinct features, necessitating a comprehensive approach that includes immunohistochemistry (IHC) and genetic testing for an accurate diagnosis. This study underscores the importance of recognizing SC as a distinct pathological entity to ensure appropriate patient management and improve outcomes.
分泌性癌（SC）是临床医生中相对较新且认识较少的涎腺癌亚型。我们研究的目的是通过对5例诊断为SC的患者的临床表现、病理特征和治疗结果进行深入分析，来阐明这种罕见的疾病实体。我们还试图促进对与SC相关的诊断标准和预后因素的理解。
在广东省人民医院接受治疗的患者年龄在33岁至40岁之间，平均年龄为33岁。值得注意的是，最初没有患者报告疼痛或发现肿块；然而，随着时间的推移，肿块逐渐变大。磁共振成像（MRI）等诊断性影像学检查将4例分类为良性，1例分类为低级别恶性。我们详细记录了这些患者的诊断和治疗过程，包括临床数据、组织病理学发现及后续治疗反应。
我们的研究结果表明，SC的预后良好。然而，SC的临床表现缺乏明显特征，需要采用包括免疫组织化学（IHC）和基因检测在内的综合方法进行准确诊断。本研究强调了将SC识别为一种独特病理实体对于确保适当的患者管理和改善治疗结果的重要性。
