• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种用于个体化预测甲状腺乳头状癌颈部淋巴结转移的列线图。

A nomogram for individualized prediction for cervical lymph node metastasis of papillary thyroid carcinoma.

作者信息

Zhou Juan, Zhao Benxin, Liu Lingling, Shi Kexin

机构信息

Department of Ultrasonography, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Department of Radiation Oncology, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China.

出版信息

Gland Surg. 2024 Nov 30;13(11):1965-1976. doi: 10.21037/gs-24-277. Epub 2024 Nov 26.

DOI:10.21037/gs-24-277
PMID:39678405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11635566/
Abstract

BACKGROUND

Cervical lymph node metastasis in papillary thyroid carcinoma plays a crucial role in the development of surgical strategy for thyroid patients. The aim of this study was to determine the predictors of cervical lymph node metastasis based on ultrasound features of papillary thyroid carcinoma, and to develop and validate nomogram to help predict cervical lymph node metastasis.

METHODS

Patients who underwent thyroid ultrasound examination in Department of Ultrasonography of The First Affiliated Hospital of Nanjing Medical University between January 1, 2021 and October 31, 2021 were selected. Patients with at least one Thyroid Imaging Reporting and Data System (TI-RADS) class 4 or higher nodule and postoperative pathologically confirmed primary papillary thyroid carcinoma with cervical lymph node metastasis were identified or not, and ultrasound image characteristics of the nodules were recorded to screen for cervical lymph node metastasis predictors. Subsequently, nomogram was developed and validated to help predict cervical lymph node metastasis.

RESULTS

The overall echogenicity of the thyroid gland, the number of malignant nodules, nodule left-right diameter, the location of the nodules, the relationship between the nodules and the thyroid capsule, and the elasticity score of the nodules were considered to be independent predictors of papillary thyroid carcinoma related cervical lymph node metastasis; the model had a good discrimination rate.

CONCLUSIONS

We developed a nomogram to predict metastasis in the neck lymph nodes of papillary thyroid carcinoma, and the nomogram showed good performance for prediction aspects.

摘要

背景

甲状腺乳头状癌的颈部淋巴结转移在甲状腺患者手术策略的制定中起着关键作用。本研究的目的是基于甲状腺乳头状癌的超声特征确定颈部淋巴结转移的预测因素，并开发和验证列线图以帮助预测颈部淋巴结转移。

方法

选取2021年1月1日至2021年10月31日在南京医科大学第一附属医院超声科接受甲状腺超声检查的患者。确定有至少一个甲状腺影像报告和数据系统（TI-RADS）4类或更高类别结节且术后病理证实为原发性甲状腺乳头状癌伴或不伴颈部淋巴结转移的患者，并记录结节的超声图像特征以筛查颈部淋巴结转移的预测因素。随后，开发并验证列线图以帮助预测颈部淋巴结转移。

结果

甲状腺的整体回声、恶性结节数量、结节左右径、结节位置、结节与甲状腺包膜的关系以及结节的弹性评分被认为是甲状腺乳头状癌相关颈部淋巴结转移的独立预测因素；该模型具有良好的区分率。

结论

我们开发了一种列线图来预测甲状腺乳头状癌颈部淋巴结转移，该列线图在预测方面表现良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/24e89f66649c/gs-13-11-1965-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/baadcd973912/gs-13-11-1965-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/3f190824f048/gs-13-11-1965-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/9984fc07c5ee/gs-13-11-1965-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/bb3fcdf20660/gs-13-11-1965-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/513da08f613d/gs-13-11-1965-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/24e89f66649c/gs-13-11-1965-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/baadcd973912/gs-13-11-1965-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/3f190824f048/gs-13-11-1965-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/9984fc07c5ee/gs-13-11-1965-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/bb3fcdf20660/gs-13-11-1965-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/513da08f613d/gs-13-11-1965-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf9/11635566/24e89f66649c/gs-13-11-1965-f6.jpg

相似文献

1
A nomogram for individualized prediction for cervical lymph node metastasis of papillary thyroid carcinoma.一种用于个体化预测甲状腺乳头状癌颈部淋巴结转移的列线图。
Gland Surg. 2024 Nov 30;13(11):1965-1976. doi: 10.21037/gs-24-277. Epub 2024 Nov 26.
2
Predictors and a Prediction Model for Central Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma (cN0).预测甲状腺乳头状癌（cN0）中央颈部淋巴结转移的预测因子和预测模型。
Front Endocrinol (Lausanne). 2022 Jan 27;12:789310. doi: 10.3389/fendo.2021.789310. eCollection 2021.
3
Risk factors and prediction models of lymph node metastasis in papillary thyroid carcinoma based on clinical and imaging characteristics.基于临床和影像特征的甲状腺乳头状癌淋巴结转移的危险因素及预测模型
Postgrad Med. 2023 Mar;135(2):121-127. doi: 10.1080/00325481.2022.2135840. Epub 2022 Oct 18.
4
Constructing a nomogram based on the distribution of thyroid nodules and suspicious lateral cervical lymph nodes in fine-needle aspiration biopsies to predict metastasis in papillary thyroid carcinoma.构建基于甲状腺结节和细针穿刺活检可疑侧颈部淋巴结分布的列线图预测甲状腺乳头状癌转移。
Front Endocrinol (Lausanne). 2023 Nov 28;14:1242061. doi: 10.3389/fendo.2023.1242061. eCollection 2023.
5
Prediction Model of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma.甲状腺乳头状癌颈淋巴结转移预测模型。
Cancer Control. 2024 Jan-Dec;31:10732748241295347. doi: 10.1177/10732748241295347.
6
Combining Thyroglobulin Levels in Lymph Node Wash-out Fluid with TI-RADS to Predict Lymph Node Metastasis in Papillary Thyroid Carcinoma.联合甲状腺球蛋白水平与TI-RADS对甲状腺乳头状癌颈部淋巴结洗脱液进行分析以预测淋巴结转移
Malawi Med J. 2025 Feb 4;36(5):298-302. doi: 10.4314/mmj.v36i5.1. eCollection 2025 Feb.
7
The anteroposterior diameter of nodules in the risk assessment of papillary thyroid microcarcinoma.甲状腺微小乳头状癌风险评估中结节的前后径
Medicine (Baltimore). 2018 Mar;97(10):e9712. doi: 10.1097/MD.0000000000009712.
8
[Study on the relationship between ultrasonographic features of papillary thyroid carcinoma and central cervical lymph node metastasis].甲状腺乳头状癌超声特征与中央区颈部淋巴结转移关系的研究
Zhonghua Zhong Liu Za Zhi. 2018 Mar 23;40(3):196-200. doi: 10.3760/cma.j.issn.0253-3766.2018.03.007.
9
Preoperative prediction of central lymph node metastasis in cN0T1/T2 papillary thyroid carcinoma: A nomogram based on clinical and ultrasound characteristics.术前预测 cN0T1/T2 期甲状腺乳头状癌中央区淋巴结转移：基于临床和超声特征的列线图
Eur J Surg Oncol. 2022 Jun;48(6):1272-1279. doi: 10.1016/j.ejso.2022.04.001. Epub 2022 Apr 6.
10
Conventional ultrasound combined with contrast-enhanced ultrasound predicts lateral lymph node metastasis in papillary thyroid carcinoma.传统超声联合超声造影可预测甲状腺乳头状癌的侧方淋巴结转移。
Clin Hemorheol Microcirc. 2025;89(1):83-94. doi: 10.3233/CH-242217.

本文引用的文献

1
The model for predicting the central lymph node metastasis in cN0 papillary thyroid microcarcinoma with Hashimoto's thyroiditis.预测伴有桥本甲状腺炎的 cN0 期甲状腺微小乳头状癌中央区淋巴结转移的模型。
Front Endocrinol (Lausanne). 2024 Apr 30;15:1330896. doi: 10.3389/fendo.2024.1330896. eCollection 2024.
2
Nomogram model based on preoperative clinical characteristics of unilateral papillary thyroid carcinoma to predict contralateral medium-volume central lymph node metastasis.基于单侧甲状腺乳头状癌术前临床特征的列线图模型预测对侧中等体积中央淋巴结转移。
Front Endocrinol (Lausanne). 2024 Feb 12;14:1271446. doi: 10.3389/fendo.2023.1271446. eCollection 2023.
3
TIPARP as a prognostic biomarker and potential immunotherapeutic target in male papillary thyroid carcinoma.
TIPARP作为男性乳头状甲状腺癌的预后生物标志物和潜在免疫治疗靶点。
Cancer Cell Int. 2024 Jan 17;24(1):34. doi: 10.1186/s12935-024-03223-6.
4
Iodine nutrition and papillary thyroid cancer.碘营养与甲状腺乳头状癌。
Front Nutr. 2022 Oct 20;9:1022650. doi: 10.3389/fnut.2022.1022650. eCollection 2022.
5
Nomogram to Assess the Risk of Central Cervical Lymph Node Metastasis in Patients With Clinical N0 Papillary Thyroid Carcinoma.评估临床 N0 期甲状腺乳头状癌患者中央颈部淋巴结转移风险的列线图。
Endocr Pract. 2021 Dec;27(12):1175-1182. doi: 10.1016/j.eprac.2021.06.010. Epub 2021 Jun 24.
6
Clinicopathological Significance of Papillary Thyroid Carcinoma Located in the Isthmus: A Meta-Analysis.甲状腺峡部乳头状癌的临床病理意义：一项荟萃分析。
World J Surg. 2021 Sep;45(9):2759-2768. doi: 10.1007/s00268-021-06178-1. Epub 2021 Jun 11.
7
Ultrasound-Based Radiomic Nomogram for Predicting Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma.基于超声的放射组学列线图预测甲状腺乳头状癌侧颈淋巴结转移。
Acad Radiol. 2021 Dec;28(12):1675-1684. doi: 10.1016/j.acra.2020.07.017. Epub 2020 Aug 8.
8
Contemporary Debates in Adult Papillary Thyroid Cancer Management.当代成人甲状腺乳头癌管理的争议。
Endocr Rev. 2019 Dec 1;40(6):1481-1499. doi: 10.1210/er.2019-00085.
9
Nomogram for predicting central lymph node metastasis in papillary thyroid microcarcinoma: A retrospective cohort study of 8668 patients.预测甲状腺微小乳头状癌中央区淋巴结转移的列线图：一项回顾性队列研究，纳入 8668 例患者。
Int J Surg. 2018 Jul;55:98-102. doi: 10.1016/j.ijsu.2018.05.023. Epub 2018 May 25.
10
Extent of central lymph node dissection for papillary thyroid carcinoma in the isthmus.甲状腺峡部乳头状癌中央区淋巴结清扫范围
Ann Surg Treat Res. 2018 May;94(5):229-234. doi: 10.4174/astr.2018.94.5.229. Epub 2018 Apr 30.