Zhang Shasha, Meng Fangeng, Zhou Chao, Zhang Yiwen, Liu Huaqin, Rong Yuanyuan
Department of Anesthesiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Department of General Internal Medicine, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, Hebei, China.
Front Oncol. 2024 Nov 29;14:1477922. doi: 10.3389/fonc.2024.1477922. eCollection 2024.
Early mortality rate in patients with high-risk pulmonary embolism(PE) is extremely high. Prompt and effective reduction of the thrombus load, and restoration of pulmonary circulation may successfully treat such patients. For patients with hemodynamic instability and high-risk acute PE, the guidelines recommend catheter directed therapy (CDT). Such patients are at increased risk during perioperative period and need considerable attention from anesthesiologists. Herein, we describe a case of acute right heart failure in a patient undergoing AngioJet PE.
A 59-year-old woman with lung cancer had been prescribed anticoagulant therapy for PE six months ago. She discontinued using the drugs on her own two months ago. One week ago, she developed chest tightness and shortness of breath, leading to the diagnosis of another PE episode. An AngioJet pulmonary embolectomy and inferior vena cava filter implantation were urgently needed under general anesthesia. During surgery, after inserting the AngioJet Solent catheter into the right lower lobe artery, she developed severe hypotension 5 s after thrombolysis with urokinase, with no obvious improvement after administration of pressor drugs; hence, pulmonary vasospasm was considered. The anesthesiologist implemented a series of resuscitation measures such as discontinuing the surgical stimulation; chest compressions; and administering pure oxygen, vasoactive drugs, and adequate anticoagulation to ensure patient safety during the perioperative period and a smooth operation.
Pulmonary artery spasm caused by AngioJet pulmonary artery embolization is a rare complication and may be life-threatening. Low left ventricular output and acute right heart failure may occur due to pulmonary spasm, which requires early identification, inhalation of pure oxygen, circulatory support, anticoagulation, and thrombolysis.
高危肺栓塞(PE)患者的早期死亡率极高。迅速有效地降低血栓负荷并恢复肺循环可能成功治疗此类患者。对于血流动力学不稳定和高危急性PE患者,指南推荐导管定向治疗(CDT)。此类患者围手术期风险增加,需要麻醉医生给予相当多的关注。在此,我们描述一例接受AngioJet肺栓塞治疗患者发生急性右心衰竭的病例。
一名59岁肺癌女性患者6个月前因PE接受抗凝治疗。2个月前她自行停药。1周前,她出现胸闷和气促,导致诊断为再次发生PE发作。急需在全身麻醉下进行AngioJet肺动脉血栓切除术和下腔静脉滤器植入术。手术过程中,将AngioJet Solent导管插入右下叶动脉后,用尿激酶溶栓5秒后她出现严重低血压,给予升压药后无明显改善;因此,考虑为肺血管痉挛。麻醉医生实施了一系列复苏措施,如停止手术刺激;胸外按压;给予纯氧、血管活性药物和充分抗凝,以确保患者围手术期安全和手术顺利进行。
AngioJet肺动脉栓塞引起的肺动脉痉挛是一种罕见的并发症,可能危及生命。肺痉挛可能导致左心室输出量降低和急性右心衰竭,这需要早期识别、吸入纯氧、循环支持、抗凝和溶栓。