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病例报告：关节腔内恶性孤立性纤维瘤1例并文献复习

Case report: A rare case of malignant solitary fibrous tumor within the joint cavity with review of the literature.

作者信息

Wang Xiao-Jie, Zhou Jia-Ping, Pan Yao, Yu Ri-Sheng

机构信息

Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

出版信息

Front Oncol. 2024 Nov 29;14:1463362. doi: 10.3389/fonc.2024.1463362. eCollection 2024.

DOI:10.3389/fonc.2024.1463362
PMID:39678501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11638052/
Abstract

Solitary fibrous tumors (SFTs) are classified as fibroblastic/myofibroblastic tumors that originate from CD34-positive dendritic cells and usually occur in the pleura. In this paper, we describe a case of SFT within the joint cavity of the left knee. A 60-year-old man was admitted to hospital due to swelling in the left knee for the past 8 months without relevant trauma history. X-ray, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET-CT) presented a large, ill-circumscribed, hypervascular, and highly enhanced mass with eccentric calcification and peripheral, intra-lesional vessels. Subsequently, the patient underwent surgical resection. Postoperative pathology confirmed the neoplastic cells to be positive for CD34, Bcl-2, and SATA6, therefore was finally diagnosed as malignant SFT. The patient developed bone metastases within 1 year after surgery. SFT in the joint cavity is rare, and it is difficult to make a preoperative diagnosis.

摘要

孤立性纤维性肿瘤（SFTs）被归类为起源于CD34阳性树突状细胞的成纤维细胞/肌成纤维细胞肿瘤，通常发生于胸膜。在本文中，我们描述了一例发生于左膝关节腔内的SFT病例。一名60岁男性因左膝肿胀8个月入院，无相关外伤史。X线、计算机断层扫描（CT）、磁共振成像（MRI）和正电子发射断层扫描-计算机断层扫描（PET-CT）显示为一个大的、边界不清、血管丰富且强化明显的肿块，伴有偏心钙化及外周和瘤内血管。随后，患者接受了手术切除。术后病理证实肿瘤细胞CD34、Bcl-2和SATA6呈阳性，因此最终诊断为恶性SFT。患者术后1年内发生了骨转移。关节腔内的SFT罕见，术前诊断困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a517/11638052/c360c5086e0c/fonc-14-1463362-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a517/11638052/33a147bcfec6/fonc-14-1463362-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a517/11638052/62f5336dea0e/fonc-14-1463362-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a517/11638052/f27021ae4d87/fonc-14-1463362-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a517/11638052/c360c5086e0c/fonc-14-1463362-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a517/11638052/33a147bcfec6/fonc-14-1463362-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a517/11638052/62f5336dea0e/fonc-14-1463362-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a517/11638052/f27021ae4d87/fonc-14-1463362-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a517/11638052/c360c5086e0c/fonc-14-1463362-g004.jpg

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Skeletal Radiol. 2022 Apr;51(4):807-817. doi: 10.1007/s00256-021-03894-6. Epub 2021 Aug 25.
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The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives.2020 年世界卫生组织软组织肿瘤分类：新闻与展望。
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