外周血中性粒细胞与淋巴细胞比值、淋巴细胞与单核细胞比值及血小板与淋巴细胞比值在子宫内膜癌中的意义
Significance of the neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, and platelet-lymphocyte ratio in peripheral blood for endometrial cancer.
作者信息
Huo Di, Yang Li
机构信息
Department of Medicine, Huanghuai University Zhumadian 463000, Henan, China.
出版信息
Am J Transl Res. 2024 Nov 15;16(11):6689-6698. doi: 10.62347/QNHR2387. eCollection 2024.
OBJECTIVE
To evaluate the diagnostic value of the expression of the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in distinguishing endometrial cancer from benign uterine lesions.
METHODS
In this retrospective analysis, clinical data were collected from 112 patients treated at Hengshui People's Hospital (Harrison International Peace Hospital) between January 2022 and December 2023. The cohort comprised 56 patients diagnosed with endometrial cancer and 56 patients with benign uterine lesions, matched 1:1. Demographic details, comorbidities, and serological parameters - including WBC, RBC, Hb, MPV, neutrophil, lymphocyte, monocyte, and platelet counts - were recorded. NLR, LMR, and PLR values were subsequently calculated.
RESULTS
Significant serological differences were observed between the endometrial cancer and benign lesion groups, including NLR (4.25 ± 1.23 vs. 2.18 ± 0.95, P < 0.001), LMR (3.12 ± 0.98 vs. 5.08 ± 1.75, P < 0.001), and PLR (201.23 ± 45.66 vs. 150.27 ± 30.45, P < 0.001). Correlation analysis indicated a strong association between endometrial cancer and NLR (r = 0.689, P < 0.001), LMR (r = -0.572, P < 0.001), and PLR (r = 0.552, P < 0.001). ROC analysis demonstrated that NLR (AUC = 0.91) offered superior diagnostic value relative to LMR (AUC = 0.841) and PLR (AUC = 0.83). Logistic regression identified significant associations for NLR ≥ 3.4 (OR = 69.173, P < 0.001), LMR ≥ 4.055 (OR = 0.048, P < 0.001), and PLR ≥ 150.445 (OR = 18.134, P = 0.002). DeLong's test revealed no significant differences in diagnostic performance among the ratios (NLR vs. LMR, P = 0.149; NLR vs. PLR, P = 0.08; LMR vs. PLR, P = 0.842).
CONCLUSION
NLR, LMR, and PLR are valuable hematological markers for diagnosing endometrial cancer, with NLR demonstrating the highest sensitivity and specificity. These findings support the inclusion of these serological parameters in routine diagnostic protocols to enhance the accurate identification of endometrial cancer.
目的
评估中性粒细胞与淋巴细胞比值（NLR）、淋巴细胞与单核细胞比值（LMR）及血小板与淋巴细胞比值（PLR）在鉴别子宫内膜癌与子宫良性病变中的诊断价值。
方法
在这项回顾性分析中，收集了2022年1月至2023年12月在衡水市人民医院（哈励逊国际和平医院）接受治疗的112例患者的临床资料。该队列包括56例诊断为子宫内膜癌的患者和56例子宫良性病变患者，按1:1匹配。记录人口统计学细节、合并症及血清学参数，包括白细胞、红细胞、血红蛋白、平均血小板体积、中性粒细胞、淋巴细胞、单核细胞及血小板计数。随后计算NLR、LMR和PLR值。
结果
子宫内膜癌组与良性病变组之间观察到显著的血清学差异，包括NLR（4.25±1.23 vs. 2.18±0.95，P<0.001）、LMR（3.12±0.98 vs. 5.08±1.75，P<0.001）和PLR（201.23±45.66 vs. 150.27±30.45，P<0.001）。相关性分析表明子宫内膜癌与NLR（r = 0.689，P<0.001）、LMR（r = -0.572，P<0.001）和PLR（r = 0.552，P<0.001）之间存在强关联。受试者工作特征（ROC）分析表明，NLR（AUC = 0.91）相对于LMR（AUC = 0.841）和PLR（AUC = 0.83）具有更高的诊断价值。逻辑回归分析确定NLR≥3.4（OR = 69.173，P<0.001）、LMR≥4.055（OR = 0.048，P<0.001）和PLR≥150.445（OR = 18.134，P = 0.002）存在显著关联。德龙检验显示各比值之间的诊断性能无显著差异（NLR与LMR比较，P = 0.149；NLR与PLR比较，P = 0.08；LMR与PLR比较，P = 0.842）。
结论
NLR、LMR和PLR是诊断子宫内膜癌有价值的血液学标志物，其中NLR的敏感性和特异性最高。这些发现支持将这些血清学参数纳入常规诊断方案，以提高子宫内膜癌的准确识别率。
Zotero 插件