Qin Xiaomin, Chen Qi, Zhu Zibo, Li Jinjin, Kang Xu
Department of Dermatology, Guangdong Provincial Hospital of Chinese Medicine Guangzhou 510120, Guangdong, China.
Am J Transl Res. 2024 Nov 15;16(11):6593-6603. doi: 10.62347/RFQN2285. eCollection 2024.
Sulfur cream is reported to relieve itching and treat skin diseases caused by bacterial, fungal, and scabies infections. However, there is limited data on the efficacy of sulfur cream blowing and parching combined with compound ketoconazole ointment (ketoconazole, clobetasol propionate, and neomycin sulfate) in curing palmoplantar keratotic eczema. This prospective study proposed to investigate the clinical efficacy of sulfur cream on people who suffer with palmoplantar keratotic eczema.
In total, 116 patients with palmoplantar keratotic eczema (those who met the diagnostic criteria of Expert Consensus on Standardized Diagnostic Terminology of Dermatitis and Eczematous Diseases) were chosen and divided into a control group (C, n = 58) and a study group (S, n = 58) depending on the treatment method. Patients in group C were cured with compound ketoconazole cream, while those in group S were given sulfur cream blowing and parching (10-15 min, once in the morning and once in the evening, with 4 weeks as a course of treatment) combined with compound ketoconazole cream treatment. Scores of erythema, keratinization, scales, chapping, pruritus, quality of life, and psychological status of patients were evaluated before and 4 weeks treatment.
The overall response rate (93% 79%) and scores of quality of life, physiological burden, and social interaction of patients of group S were higher than those of group C ( < 0.05), and the incidence of adverse reactions and scores of self-rating anxiety scale, self-rating depressive scale, erythema, keratinization, scales, and skin lesions were lower in group S than those in the group C ( < 0.05) 4 weeks after treatment. In addition, pruritus scores at 1, 2, and 4 weeks after treatments were fewer in patients of group S than those in group C ( < 0.05).
Sulfur cream blowing and parching for 4 weeks of treatment combined with compound ketoconazole cream is more effective than compound ketoconazole cream alone for 4 weeks in treating palmoplantar keratotic eczema.
据报道，硫磺乳膏可缓解瘙痒，并治疗由细菌、真菌和疥疮感染引起的皮肤病。然而，关于硫磺乳膏熏烤联合复方酮康唑软膏（酮康唑、丙酸氯倍他索和硫酸新霉素）治疗掌跖角化性湿疹疗效的数据有限。本前瞻性研究旨在探讨硫磺乳膏对掌跖角化性湿疹患者的临床疗效。
共选取116例掌跖角化性湿疹患者（符合《皮炎湿疹类疾病标准化诊疗术语专家共识》诊断标准者），根据治疗方法分为对照组（C组，n = 58）和研究组（S组，n = 58）。C组患者采用复方酮康唑乳膏治疗，而S组患者采用硫磺乳膏熏烤（10 - 15分钟，早晚各1次，以4周为一个疗程）联合复方酮康唑乳膏治疗。在治疗前及治疗4周后评估患者的红斑、角化、鳞屑、皲裂、瘙痒、生活质量和心理状态评分。
治疗4周后，S组患者的总有效率（93% 79%）以及生活质量、生理负担和社会交往评分均高于C组（P < 0.05），且S组的不良反应发生率以及自评焦虑量表、自评抑郁量表、红斑、角化、鳞屑和皮肤损害评分均低于C组（P < 0.05）。此外，治疗后1周、2周和4周时，S组患者的瘙痒评分低于C组（P < 0.05）。
硫磺乳膏熏烤4周联合复方酮康唑乳膏治疗掌跖角化性湿疹的效果优于单独使用复方酮康唑乳膏治疗4周。
