Exploring Bioactive Potential of WAE1 from Wadi El-Natron, Egypt.

This study aimed to investigate the bioactive metabolites produced by WAE1, an actinomycete isolated from El-Hamara Lake in Egypt. The discovery of new bioactive compounds from natural sources is crucial for the advancement of therapeutic treatments, and this study aimed to contribute to this field by exploring the potential of WAE1 as a source of such compounds. WAE1 was screened for its ability to produce antimicrobial, antioxidant, and anti-inflammatory metabolites. The results revealed that WAE1 exhibited strong antimicrobial activity against and moderate activity against , , and . WAE1 also displayed antioxidant activity through scavenging free radicals and chelating iron, and moderate anti-inflammatory activity as determined by its IC value. The isolate's demonstration of L-asparaginase activity suggests that WAE1 is a promising source of bioactive compounds with potential therapeutic uses. The high salinity and alkalinity of El-Hamara Lake, which create favorable conditions for the production of bioactive metabolites, further add to its potential as a source of actinomycetes strains with bioactive properties. These findings make both WAE1 and El-Hamara Lake valuable subjects for further exploration in the field of bioactive compounds.