Dereski W, Petty H R
Immunology. 1985 Feb;54(2):397-9.
Mononuclear phagocytes play a central role in the removal of immune complexes from the circulation. Cell surface receptors for the Fc domain of IgG mediate, at least in part, the recognition and internalization of particulate and soluble immune complexes. Recently, there have been significant advances in understanding the structural and functional aspects of Fc receptors (Leslie & Alexander, 1979; Zuckerman & Douglas, 1979). However, the post-receptor binding events which trigger endocytosis of immune complexes are not well understood. In the present communication, we employ the membrane-impermeable reagent 5,5′-dithiobis (nitrobenzoic acid), DTNB, to demonstrate that cell surface sulphydryl groups are required for the endocytosis, but not recognition of immune complexes.
单核吞噬细胞在从循环中清除免疫复合物方面发挥着核心作用。IgG的Fc结构域的细胞表面受体至少部分介导了颗粒性和可溶性免疫复合物的识别与内化。最近，在理解Fc受体的结构和功能方面取得了重大进展（莱斯利和亚历山大，1979年；朱克曼和道格拉斯，1979年）。然而，触发免疫复合物内吞作用的受体后结合事件尚未得到很好的理解。在本通讯中，我们使用膜不透性试剂5,5'-二硫代双（硝基苯甲酸），即DTNB，来证明细胞表面巯基是免疫复合物内吞作用所必需的，但不是免疫复合物识别所必需的。
