鼠疟：AXB/BXA重组近交系小鼠对查巴迪疟原虫的抗性
Murine malaria: resistance of AXB/BXA recombinant inbred mice to Plasmodium chabaudi.
作者信息
Stevenson M M, Skamene E
出版信息
Infect Immun. 1985 Feb;47(2):452-6. doi: 10.1128/iai.47.2.452-456.1985.
Abstract
The level of resistance to infection with Plasmodium chabaudi is genetically controlled. We have previously reported that a single dominant gene is responsible for the variation in host resistance to malaria between susceptible A/J- and resistant C57BL-derived mice. In the present study, recombinant inbred strain analysis was performed with AXB/BXA recombinant inbred strains derived from A/J and C57BL/6 progenitors. Typing of 17 AXB/BXA recombinant inbred strains confirmed the unigenic control of inheritance in this particular strain combination and allowed us to demonstrate genetic linkage between the traits of resistance (defined as a prolonged survival and a low peak parasitemia) and the magnitude of splenomegaly. The influence of sex on the course of infection, which we previously reported in the examination of segregating populations (Stevenson et al., Infect. Immun. 38:80-88, 1982), was again demonstrated in the survey of RI strains.
摘要
对查巴迪疟原虫感染的抵抗力水平受基因控制。我们之前报道过，一个单一的显性基因负责易感的A/J小鼠和抗性的C57BL衍生小鼠之间宿主对疟疾抵抗力的差异。在本研究中，对源自A/J和C57BL/6祖代的AXB/BXA重组近交系进行了重组近交系分析。对17个AXB/BXA重组近交系的分型证实了在这种特定品系组合中遗传的单基因控制，并使我们能够证明抗性性状（定义为延长存活时间和低峰值寄生虫血症）与脾肿大程度之间的遗传连锁。我们之前在对分离群体的研究中报道过的性别对感染过程的影响（Stevenson等人，《感染与免疫》38:80 - 88，1982），在对重组近交系的调查中再次得到证实。
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本文引用的文献
1
Backcross Studies on the Genetics of Resistance to Malaria in Mice.小鼠对疟疾抗性遗传学的回交研究。
Genetics. 1955 Sep;40(5):620-6. doi: 10.1093/genetics/40.5.620.
2
[The influence of strain, sex and age of mice on infection with Plasmodium berghei].[小鼠的品系、性别和年龄对伯氏疟原虫感染的影响]
J Infect Dis. 1953 Jul-Aug;93(1):96-100. doi: 10.1093/infdis/93.1.96.
3
Malaria in asplenic mice: effects of splenectomy, congenital asplenia, and splenic reconstitution on the course of infection.无脾小鼠的疟疾：脾切除术、先天性无脾和脾重建对感染病程的影响。
Am J Trop Med Hyg. 1980 Nov;29(6):1138-42. doi: 10.4269/ajtmh.1980.29.1138.
4
Demonstration of a lipopolysaccharide-induced cytostatic effect on malarial parasites.脂多糖对疟原虫的细胞生长抑制作用的证明。
Infect Immun. 1981 Aug;33(2):343-7. doi: 10.1128/iai.33.2.343-347.1981.
5
Differences in susceptibility of various mouse strains to haemoprotozoan infections: possible correlation with natural killer activity.不同小鼠品系对血原虫感染易感性的差异：与自然杀伤活性的可能关联。
Parasite Immunol. 1980 Winter;2(4):277-92. doi: 10.1111/j.1365-3024.1980.tb00059.x.
6
Murine malaria: genetic control of resistance to Plasmodium chabaudi.鼠疟：对查巴迪疟原虫抗性的遗传控制
Infect Immun. 1982 Oct;38(1):80-8. doi: 10.1128/iai.38.1.80-88.1982.
7
Genetic regulation of resistance to intracellular pathogens.对细胞内病原体抗性的遗传调控。
Nature. 1982 Jun 10;297(5866):506-9. doi: 10.1038/297506a0.
8
Chronic, patent Plasmodium berghei malaria in splenectomized mice.脾切除小鼠中的慢性、开放性伯氏疟原虫疟疾
Infect Immun. 1982 Mar;35(3):880-6. doi: 10.1128/iai.35.3.880-886.1982.
9
Endotoxin-induced serum factor kills malarial parasites in vitro.内毒素诱导的血清因子在体外可杀死疟原虫。
Infect Immun. 1981 Jul;33(1):83-9. doi: 10.1128/iai.33.1.83-89.1981.
10
Immunity to Plasmodium chabaudi adami in the B-cell-deficient mouse.B细胞缺陷小鼠对查巴迪疟原虫的免疫
Nature. 1981 Mar 12;290(5802):143-5. doi: 10.1038/290143a0.
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