Should we pay more attention to the potential link between and esophageal cancer in Asian countries.

The presence of () infection has been indicated to have a protective influence on esophageal cancer (EC) in some studies, but its specific impact on the risk of esophageal squamous cell carcinoma and esophageal adenocarcinoma remains inconclusive. This manuscript comment addresses the recent study by López-Gómez . Despite it was a retrospective observational study without a control group, this study revealed a notably low prevalence of infection among EC patients, indicating a potential association between and EC in Spain. It is important to note that the relationship between and the risk of EC varies geographically. We also conducted a meta-analysis focusing on this association in Asian populations to offer precise clinical insights. However, no significant correlation between infection and EC was identified, suggesting that the perceived protective effect of against EC may have been overestimated in the Asian population.