Liu Jie, Liu Ying-Ling
Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, Anhui Province, China.
World J Gastroenterol. 2024 Dec 14;30(46):4958-4963. doi: 10.3748/wjg.v30.i46.4958.
The presence of () infection has been indicated to have a protective influence on esophageal cancer (EC) in some studies, but its specific impact on the risk of esophageal squamous cell carcinoma and esophageal adenocarcinoma remains inconclusive. This manuscript comment addresses the recent study by López-Gómez . Despite it was a retrospective observational study without a control group, this study revealed a notably low prevalence of infection among EC patients, indicating a potential association between and EC in Spain. It is important to note that the relationship between and the risk of EC varies geographically. We also conducted a meta-analysis focusing on this association in Asian populations to offer precise clinical insights. However, no significant correlation between infection and EC was identified, suggesting that the perceived protective effect of against EC may have been overestimated in the Asian population.
在一些研究中，（）感染的存在已被表明对食管癌（EC）具有保护作用，但其对食管鳞状细胞癌和食管腺癌风险的具体影响仍尚无定论。本手稿评论涉及López-Gómez最近的研究。尽管这是一项没有对照组的回顾性观察研究，但该研究显示EC患者中（）感染的患病率极低，表明在西班牙（）与EC之间存在潜在关联。需要注意的是，（）与EC风险之间的关系因地域而异。我们还针对亚洲人群中这种关联进行了荟萃分析，以提供精确的临床见解。然而，未发现（）感染与EC之间存在显著相关性，这表明在亚洲人群中，（）对EC的所谓保护作用可能被高估了。
