Abed Heba, Sabouni Rana, Ghommem Mehdi
Biomedical Engineering Program, Department of Chemical and Biological Engineering, American University of Sharjah Sharjah UAE.
Department of Chemical and Biological Engineering, American University of Sharjah Sharjah UAE
RSC Adv. 2024 Dec 13;14(53):39472-39497. doi: 10.1039/d4ra07476a. eCollection 2024 Dec 10.
Cholesterol detection is essential for early diagnosis and monitoring of cholesterol-related diseases, such as atherosclerosis, hypercholesterolemia, and liver diseases. A variety of nanomaterials have been designed and synthesized for cholesterol detection electrochemical and spectrophotometric techniques. Metal organic frameworks (MOFs) have emerged as promising detector materials for cholesterol sensing. Recent research explores MOFs as spectrophotometric cholesterol sensors with remarkable performance in terms of limit of detection and selectivity. Given the growing interest in cholesterol sensing, and limited reviews on recent advances in the field, this review critically examines recent advances in MOF-based spectrophotometric cholesterol sensors, outlining the different mechanistic roles of MOFs in cholesterol detection. The review also highlights significant improvements, current challenges, and potential applications of MOF-based sensors for cholesterol detection in point-of-care devices and medical diagnostics.
胆固醇检测对于胆固醇相关疾病（如动脉粥样硬化、高胆固醇血症和肝脏疾病）的早期诊断和监测至关重要。人们已经设计并合成了多种用于胆固醇检测的纳米材料，采用电化学和分光光度技术。金属有机框架（MOF）已成为有前景的胆固醇传感检测材料。最近的研究探索将MOF用作分光光度胆固醇传感器，在检测限和选择性方面具有卓越性能。鉴于对胆固醇传感的兴趣日益浓厚，且该领域近期进展的综述有限，本综述批判性地审视了基于MOF的分光光度胆固醇传感器的最新进展，概述了MOF在胆固醇检测中的不同作用机制。该综述还强调了基于MOF的胆固醇检测传感器在即时检测设备和医学诊断中的显著改进、当前挑战及潜在应用。
