Ameen Sha M, Meenu P C, Haspel H, Kónya Z
Department of Applied and Environmental Chemistry, Faculty of Science and Informatics, University of Szeged Rerrich Béla tér 1 Szeged H-6720 Hungary
Department of Chemistry, Birla Institute of Technology and Science Hyderabad Campus 500078 India
RSC Adv. 2024 Aug 5;14(34):24561-24573. doi: 10.1039/d4ra04104f.
Metal based catalysts and electrodes are versatile tools known for their redox properties, catalytic efficiency, and stability under various conditions. Despite the absence of significant scientific hurdles, the utilization of these methods in cholesterol detection, particularly in non-enzymatic approaches, has been relatively underexplored. To this end, there is a pressing need to delve deeper into existing metal-based systems used in non-enzymatic cholesterol sensing, with the goal of fostering the development of innovative practical solutions. Various electrode systems, such as those employing Ni, Ti, Cu, Zn, W, Mn, and Fe, have already been reported for non-enzymatic cholesterol detection, some of them elucidated sensing mechanisms and potential in physiological detection. A detailed mechanistic understanding of oxide-based cholesterol sensors, along with the methodologies for constructing such systems, holds promise of advancing the exploration of practical applications. This review aims to provide a broad perspective on metal oxide systems and their characteristics that are conducive to non-enzymatic cholesterol sensing. It is intended to serve as a springboard with offering a guide to the design and development of efficient and sensitive electrochemical cholesterol sensors.
基于金属的催化剂和电极是多功能工具，以其氧化还原特性、催化效率和在各种条件下的稳定性而闻名。尽管没有重大的科学障碍，但这些方法在胆固醇检测中的应用，特别是在非酶法检测中，相对来说还未得到充分探索。为此，迫切需要更深入地研究用于非酶胆固醇传感的现有金属基系统，以促进创新实用解决方案的开发。已经报道了各种电极系统，如使用镍、钛、铜、锌、钨、锰和铁的电极系统用于非酶胆固醇检测，其中一些阐明了传感机制和生理检测中的潜力。对基于氧化物的胆固醇传感器的详细机理理解，以及构建此类系统的方法，有望推动实际应用的探索。这篇综述旨在对有利于非酶胆固醇传感的金属氧化物系统及其特性提供一个广泛的视角。它旨在作为一个跳板，为高效灵敏的电化学胆固醇传感器的设计和开发提供指导。
