Ohsawa Manato, Nishi Hiromi, Emi Manabu, Yoshikawa Toru, Hamai Yoichi, Ibuki Yuta, Kurokawa Tomoaki, Hirohata Ryosuke, Kitasaki Nao, Kawada-Matsuo Miki, Komatsuzawa Hitoshi, Kawaguchi Hiroyuki, Okada Morihito
Department of Surgical Oncology, Hiroshima University, 1-2-3-Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-0037, Japan.
Department of General Dentistry, Hiroshima University Hospital, 1-2-3-Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-0037, Japan.
J Radiat Res. 2024 Dec 16;65(Supplement_1):i126-i134. doi: 10.1093/jrr/rrae061.
Despite advances in multimodality therapy, including surgery, chemotherapy, radiation therapy and chemoradiation, the fatality rate for esophageal cancer remains high. Specifically, Fusobacterium nucleatum, due to its aggregation capacity, has shown a tendency to form biofilms. The biofilm-forming capabilities of microbial communities are of utmost importance in the context of cancer treatment, as they have been shown to drive significant losses in the efficaciousness of various cancer treatments. Therefore, elucidating the dynamics of F. nucleatum will be important for the development of effective treatments for esophageal cancer. Therefore, this review summarizes the current knowledge of F. nucleatum, its involvement in cancer and its impact on chemotherapy and radiation therapy. In conclusion, further research on the role of F. nucleatum is essential for the continued advancement of the treatment of esophageal cancer and patient care.
尽管在多模态治疗方面取得了进展，包括手术、化疗、放疗和放化疗，但食管癌的死亡率仍然很高。具体而言，具核梭杆菌由于其聚集能力，已显示出形成生物膜的倾向。微生物群落的生物膜形成能力在癌症治疗背景下至关重要，因为它们已被证明会导致各种癌症治疗效果的显著损失。因此，阐明具核梭杆菌的动态变化对于开发有效的食管癌治疗方法至关重要。因此，本综述总结了目前关于具核梭杆菌的知识、其在癌症中的作用以及对化疗和放疗的影响。总之，对具核梭杆菌作用的进一步研究对于食管癌治疗和患者护理的持续进展至关重要。
