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长崎原子弹爆炸幸存者中的骨髓增生异常综合征：与原发性及治疗相关病例的异同

Myelodysplastic syndromes among atomic bomb survivors in Nagasaki: similarities to and differences from de novo and therapy-related cases.

作者信息

Ando Koji, Miyazaki Yasushi

机构信息

Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan.

出版信息

J Radiat Res. 2024 Dec 15;65(Supplement_1):i88-i96. doi: 10.1093/jrr/rrae003.

DOI:10.1093/jrr/rrae003
PMID:39679886
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11647930/
Abstract

Epidemiological studies for atomic bomb (A-bomb) survivors clearly demonstrated that A-bomb radiation increased the risk of hematological neoplasms, such as acute and chronic leukemia, and myelodysplastic syndromes (MDS) among survivors. Several studies on MDS among survivors investigated its characteristics, and it seems that MDS among survivors has different features from those seen in de novo MDS and therapy-related MDS. In this short review, we describe the differences of clinical features, chromosomal alterations and genome aberrations among them.

摘要

针对原子弹爆炸幸存者的流行病学研究清楚地表明，原子弹辐射增加了幸存者患血液系统肿瘤的风险，如急性和慢性白血病以及骨髓增生异常综合征（MDS）。多项针对幸存者中MDS的研究调查了其特征，似乎幸存者中的MDS具有与原发性MDS和治疗相关MDS不同的特征。在这篇简短的综述中，我们描述了它们在临床特征、染色体改变和基因组畸变方面的差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b22e/11647930/bef7c5475b1e/rrae003f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b22e/11647930/72a960f895ca/rrae003f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b22e/11647930/bef7c5475b1e/rrae003f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b22e/11647930/72a960f895ca/rrae003f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b22e/11647930/bef7c5475b1e/rrae003f2.jpg

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Myelodysplastic syndromes among atomic bomb survivors in Nagasaki: similarities to and differences from de novo and therapy-related cases.长崎原子弹爆炸幸存者中的骨髓增生异常综合征：与原发性及治疗相关病例的异同
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本文引用的文献

1
Real-world data of MDS and CMML in Japan: results of JALSG clinical observational study-11 (JALSG-CS-11).日本 MDS 和 CMML 的真实世界数据：JALSG 临床观察研究-11（JALSG-CS-11）的结果。
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Myelodysplastic Syndromes.骨髓增生异常综合征
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Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.TP53 等位基因状态对骨髓增生异常综合征的基因组稳定性、临床表现和预后的影响。
Nat Med. 2020 Oct;26(10):1549-1556. doi: 10.1038/s41591-020-1008-z. Epub 2020 Aug 3.
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Genome analysis of myelodysplastic syndromes among atomic bomb survivors in Nagasaki.长崎原子弹幸存者骨髓增生异常综合征的基因组分析。
Haematologica. 2020 Jan 31;105(2):358-365. doi: 10.3324/haematol.2019.219386. Print 2020.
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Clinicopathological aspects of therapy-related acute myeloid leukemia and myelodysplastic syndrome.治疗相关性急性髓系白血病和骨髓增生异常综合征的临床病理特征。
Best Pract Res Clin Haematol. 2019 Mar;32(1):3-12. doi: 10.1016/j.beha.2019.02.007. Epub 2019 Feb 27.
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PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.PPM1D 突变驱动细胞毒性化疗后的克隆性造血。
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Onco Targets Ther. 2018 Sep 17;11:5909-5915. doi: 10.2147/OTT.S101333. eCollection 2018.
10
Chromosomal analysis of myelodysplastic syndromes among atomic bomb survivors in Nagasaki.长崎原子弹爆炸幸存者骨髓增生异常综合征的染色体分析
Br J Haematol. 2018 Feb;180(3):381-390. doi: 10.1111/bjh.15050. Epub 2017 Dec 19.