An Pei, Tong Yang, Mu Rui, Han Liang
Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Soochow University, Suzhou 215123, China.
Bioconjug Chem. 2025 Feb 19;36(2):136-145. doi: 10.1021/acs.bioconjchem.4c00537. Epub 2024 Dec 16.
The Wnt signaling pathway has a significant regulatory part in tissue development and homeostasis. Dysregulation of the Wnt signaling pathway has been associated with many diseases including cancers and various brain diseases, making this signaling pathway a promising therapeutic target for these diseases. In this review, we describe the roles of the Wnt signaling pathway in the blood-brain barrier (BBB) in intracranial tumors and peripheral tumors, from preclinical and clinical perspectives, introduce Wnt-regulated therapeutics including various types of drugs and nanomedicines as BBB modulators for brain-oriented drug delivery and as therapeutic drugs for cancer treatments, and finally discuss limitations and future perspectives for Wnt-regulated therapeutics.
Wnt信号通路在组织发育和体内平衡中具有重要的调节作用。Wnt信号通路的失调与包括癌症和各种脑部疾病在内的许多疾病相关，这使得该信号通路成为这些疾病有前景的治疗靶点。在本综述中，我们从临床前和临床角度描述了Wnt信号通路在颅内肿瘤和外周肿瘤的血脑屏障（BBB）中的作用，介绍了Wnt调节的治疗方法，包括各种类型的药物和纳米药物，它们可作为面向脑的药物递送的BBB调节剂以及癌症治疗的治疗药物，最后讨论了Wnt调节治疗方法的局限性和未来前景。
