Harb Jerry, Lin Pen-Jen, Hao Jijun
Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, 91766, USA.
College of Veterinary Medicine, Western University of Health Sciences, 309 E 2nd Street, Pomona, CA, 91766, USA.
Curr Oncol Rep. 2019 Feb 4;21(2):12. doi: 10.1007/s11912-019-0763-9.
Review current understanding of both canonical and non-canonical Wnt signaling in cancer and provide updated knowledge in current clinical trials of Wnt signaling drugs.
Important roles of both canonical and non-canonical Wnt signaling in cancer have been increasingly recognized. Recent clinical trials of several Wnt-signaling drugs have showed promising outcomes. In addition, some drugs that were originally approved for the treatment of other diseases have been recently found to block Wnt signaling, highlighting their potential to treat Wnt-dependent cancer. Dysfunction of Wnt signaling is implicated in cancer, and targeting Wnt signaling represents a useful approach to treat cancer. Current clinical trials of Wnt signaling drugs have showed promising outcomes, and repurposing the previously approved drugs for other diseases to treat Wnt-dependent cancer requires further studies.
回顾目前对癌症中经典和非经典Wnt信号通路的理解，并提供Wnt信号通路药物当前临床试验的最新知识。
经典和非经典Wnt信号通路在癌症中的重要作用已得到越来越多的认可。几种Wnt信号通路药物的近期临床试验显示出了有前景的结果。此外，一些最初被批准用于治疗其他疾病的药物最近被发现可阻断Wnt信号通路，凸显了它们治疗Wnt依赖性癌症的潜力。Wnt信号通路功能障碍与癌症有关，靶向Wnt信号通路是治疗癌症的一种有效方法。Wnt信号通路药物的当前临床试验已显示出有前景的结果，将先前批准用于其他疾病的药物重新用于治疗Wnt依赖性癌症需要进一步研究。
