Trees Alanna, Smithem Cassi, Bialick Mallorie, Kabigting Filamer
Hudson Dermatology, Kingston, New York, USA.
Dermatol Online J. 2024 Oct 15;30(5). doi: 10.5070/D330564430.
Granuloma annulare (GA) is an idiopathic inflammatory skin condition with a chronic and unpredictable course. Although localized GA is usually cleared with topical or systemic corticosteroids, generalized GA is often difficult to treat owing to the lack of treatment options and recurrence with treatment. Recent evidence has helped to elucidate the etiology behind GA, with growing confirmation for the use of JAK inhibitors as a possible treatment for GA. We present a 61-year-old woman with recalcitrant GA who responded successfully to pulse therapy upadacitinib, a JAK1 inhibitor. Our findings demonstrate the utility of this alternative and practical treatment strategy that may reduce the cumulative toxicity of upadacitinib and optimize its risk/benefit ratio.
环状肉芽肿（GA）是一种特发性炎症性皮肤病，病程慢性且不可预测。尽管局限性GA通常可通过局部或全身使用皮质类固醇清除，但全身性GA由于缺乏治疗选择且治疗后易复发，往往难以治疗。最近的证据有助于阐明GA背后的病因，越来越多的人证实使用JAK抑制剂可能是GA的一种治疗方法。我们报告了一名61岁患有顽固性GA的女性，她对JAK1抑制剂乌帕替尼脉冲疗法反应良好。我们的研究结果证明了这种替代且实用的治疗策略的有效性，该策略可能会降低乌帕替尼的累积毒性并优化其风险/效益比。
