一项关于血清素能基因多态性的多基因风险评分与社交恐惧症之间关系的双样本研究：人际适应性作为中介因素。
A two-sample study on the relationship between polygenic risk score of serotonergic polymorphisms and social phobia: Interpersonal adaptability as a mediator.
作者信息
Yang Yuting, Lan Qi, Liang Wenting, Zhou Mingzhu, Zhao Wenping, Gong Pingyuan
机构信息
College of Life Science, Northwest University, Xi'an 710069, China.
College of Life Science, Northwest University, Xi'an 710069, China; College of Medicine, Northwest University, Xi'an 710069, China; Institute of Population and Health, Northwest University, Xi'an 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 10;136:111220. doi: 10.1016/j.pnpbp.2024.111220. Epub 2024 Dec 15.
BACKGROUNDS
The influence of serotonin function on social phobia has been well-documented, yet the polygenic risk score of serotonergic polymorphisms for social phobia remains unclear.
METHODS
We assessed two aspects of social phobia (i.e., social interaction anxiety and social phobia scrutiny fear) and created a polygenic risk score of seven serotonergic polymorphisms in two independent samples.
RESULTS
The results from both samples indicated that a greater polygenic risk score, denoting a higher risk of anxiety, was associated with higher levels of social interaction anxiety and social phobia scrutinizing fear. Interestingly, the association between polygenic risk score and social interaction anxiety was mediated by interpersonal adaptability.
CONCLUSION
These findings demonstrate the importance of serotonergic polymorphisms in social phobia and unveil a psychological pathway whereby interpersonal adaptability mediates the effect of serotonergic polymorphisms on social phobia.
背景
血清素功能对社交恐惧症的影响已有充分记录，但血清素能多态性对社交恐惧症的多基因风险评分仍不明确。
方法
我们评估了社交恐惧症的两个方面（即社交互动焦虑和社交恐惧症审视恐惧），并在两个独立样本中创建了七个血清素能多态性的多基因风险评分。
结果
两个样本的结果均表明，多基因风险评分越高，表明焦虑风险越高，与社交互动焦虑和社交恐惧症审视恐惧水平越高相关。有趣的是，多基因风险评分与社交互动焦虑之间的关联由人际适应性介导。
结论
这些发现证明了血清素能多态性在社交恐惧症中的重要性，并揭示了一条心理途径，即人际适应性介导血清素能多态性对社交恐惧症的影响。
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