Han Ming-Yuan, Cao Xin-Yuan, Yang Cheng-Yan, Gao Rui-Ze, Lü Xiao-Lin, Sun Zhong-Ren, Fan Ying, Yin Hong-Na
Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150000.
Zhen Ci Yan Jiu. 2024 Dec 25;49(12):1325-1332. doi: 10.13702/j.1000-0607.20240310.
Spinal cord injury (SCI) is a highly disabling disease of the central nervous system, and seriously affects the patients' quality of life. A large number of studies have shown that programmed cell death (PCD) is an important pathological mechanism of secondary injury in SCI. As a non-drug therapy, acupuncture therapy has the characteristics of bidirectional, holistic and multi-level actions, which can target PCD pathways to play a neuroprotective effect, and has great potential in regulating PCD in the treatment of SCI. In the present paper, we systematically elaborated the PCD pathway related to SCI and summed up the possible mechanism of acupuncture underlying improvement of SCI from 1) regulating apoptosis, 2) modulating autophagy, 3) regulating pyroptosis, 4) inhibiting ferroptosis, and 5) suppressing necroptosis. These may provide a theoretical basis for acupuncture treatment of SCI and for further research in the coming years.
脊髓损伤（SCI）是一种严重致残的中枢神经系统疾病，严重影响患者的生活质量。大量研究表明，程序性细胞死亡（PCD）是SCI继发性损伤的重要病理机制。作为一种非药物疗法，针刺疗法具有双向、整体和多层次作用的特点，可靶向PCD通路发挥神经保护作用，在SCI治疗中调节PCD具有巨大潜力。在本文中，我们系统阐述了与SCI相关的PCD通路，并从1）调节凋亡、2）调节自噬、3）调节焦亡、4）抑制铁死亡和5）抑制坏死性凋亡五个方面总结了针刺改善SCI的可能机制。这些可能为针刺治疗SCI及未来的进一步研究提供理论依据。
