益生菌作为牙周炎治疗的辅助疗法——现实还是幻想——临床视角
Probiotics as an adjunctive therapy in periodontitis treatment-reality or illusion-a clinical perspective.
作者信息
Baddouri Lamyae, Hannig Matthias
机构信息
Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, Homburg, Germany.
Pharmacy, Saarland University, Saarbrucken, Germany.
出版信息
NPJ Biofilms Microbiomes. 2024 Dec 16;10(1):148. doi: 10.1038/s41522-024-00614-5.
Abstract
Periodontitis, a prevalent oral health issue, involves various microorganisms and clinical effects. This review examines probiotics as adjunctive therapy for periodontitis by analyzing forty clinical studies. Findings showed mixed results due to differences in study design, probiotic types, and clinical parameters; however, probiotics improved outcomes in severe cases. Caution is advised when interpreting these results, as longer follow-up periods reveal variability and potential regression in effects.
摘要
牙周炎是一种常见的口腔健康问题，涉及多种微生物和临床影响。本综述通过分析40项临床研究，探讨了益生菌作为牙周炎辅助治疗的效果。研究结果显示，由于研究设计、益生菌类型和临床参数的差异，结果喜忧参半；然而，益生菌在严重病例中改善了治疗效果。在解释这些结果时建议谨慎，因为更长的随访期显示出效果的变异性和潜在的回归性。
相似文献
1
Probiotics as an adjunctive therapy in periodontitis treatment-reality or illusion-a clinical perspective.益生菌作为牙周炎治疗的辅助疗法——现实还是幻想——临床视角
NPJ Biofilms Microbiomes. 2024 Dec 16;10(1):148. doi: 10.1038/s41522-024-00614-5.
2
Methods used to deliver adjunctive probiotic treatment during the non-surgical management of periodontitis: A scoping review.在牙周炎非手术治疗期间提供辅助益生菌治疗的方法：一项范围综述。
J Dent. 2025 Apr;155:105623. doi: 10.1016/j.jdent.2025.105623. Epub 2025 Feb 12.
3
Impact of systemic probiotics as adjuncts to subgingival instrumentation on the oral-gut microbiota associated with periodontitis: A randomized controlled clinical trial.全身应用益生菌作为龈下器械治疗辅助手段对与牙周炎相关的口腔-肠道微生物群的影响：一项随机对照临床试验。
J Periodontol. 2022 Jan;93(1):31-44. doi: 10.1002/JPER.21-0078. Epub 2021 Jun 19.
4
The role of probiotic bacteria in managing periodontal disease: a systematic review.益生菌在牙周疾病管理中的作用：一项系统评价
Expert Rev Anti Infect Ther. 2016 Jul;14(7):643-55. doi: 10.1080/14787210.2016.1194198. Epub 2016 Jun 3.
5
Probiotics as an Adjunct Therapy for the Treatment of Halitosis, Dental Caries and Periodontitis.益生菌作为口臭、龋齿和牙周炎治疗的辅助疗法。
Probiotics Antimicrob Proteins. 2020 Jun;12(2):325-334. doi: 10.1007/s12602-019-9521-4.
6
Clinical effects of probiotics on the treatment of gingivitis and periodontitis: a systematic review and meta-analysis.益生菌对牙龈炎和牙周炎治疗的临床效果：一项系统评价和荟萃分析。
BMC Oral Health. 2025 Apr 4;25(1):490. doi: 10.1186/s12903-025-05888-5.
7
Effect of Probiotic Supplements on the Oral Microbiota-A Narrative Review.益生菌补充剂对口腔微生物群的影响——一篇叙述性综述
Pathogens. 2024 May 16;13(5):419. doi: 10.3390/pathogens13050419.
8
Effects of adjunctive light-activated disinfection and probiotics on clinical and microbiological parameters in periodontal treatment: a randomized, controlled, clinical pilot study.辅助光活化消毒和益生菌对牙周治疗中临床及微生物学参数的影响：一项随机对照临床试验研究
Clin Oral Investig. 2021 Jun;25(6):3967-3975. doi: 10.1007/s00784-020-03727-1. Epub 2021 Feb 4.
9
Multi-function screening of probiotics to improve oral health and evaluating their efficacy in a rat periodontitis model.益生菌的多功能筛选以改善口腔健康，并在大鼠牙周炎模型中评估其功效。
Front Cell Infect Microbiol. 2023 Nov 7;13:1261189. doi: 10.3389/fcimb.2023.1261189. eCollection 2023.
10
The role of probiotics for preventing dysbiosis in periodontal disease: a randomized controlled trial.益生菌预防牙周病肠道菌群失调的作用：一项随机对照试验。
Turk J Med Sci. 2023 Dec 7;54(1):357-365. doi: 10.55730/1300-0144.5798. eCollection 2024.
引用本文的文献
1
[Prebiotics, probiotics and postbiotics-An introduction].[益生元、益生菌和后生元——简介]
HNO. 2025 Aug 5. doi: 10.1007/s00106-025-01657-6.
2
The role of probiotics and dietary interventions in the treatment of periodontitis: a pilot randomized controlled clinical trial.益生菌和饮食干预在牙周炎治疗中的作用：一项随机对照临床试验的初步研究
BMC Oral Health. 2025 Jul 31;25(1):1287. doi: 10.1186/s12903-025-06510-4.
3
Evaluation of the anti-inflammatory, antioxidant and regenerative effects of microbiota-derived postbiotics in human periodontal ligament mesenchymal stromal cells.微生物群衍生的后生元对人牙周膜间充质基质细胞的抗炎、抗氧化和再生作用的评估。
Clin Oral Investig. 2025 Apr 23;29(5):262. doi: 10.1007/s00784-025-06341-1.
4
A Potential Link Between Oral Microbiota and Female Reproductive Health.口腔微生物群与女性生殖健康之间的潜在联系。
Microorganisms. 2025 Mar 7;13(3):619. doi: 10.3390/microorganisms13030619.
5
Evaluation of Single and Multi-Strain Probiotics with Gentamicin Against O157:H7: Insights from In Vitro and In Vivo Studies.庆大霉素对单菌株和多菌株益生菌抗O157:H7的评价：来自体外和体内研究的见解
Microorganisms. 2025 Feb 19;13(2):460. doi: 10.3390/microorganisms13020460.
6
Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach.益生菌疗法作为牙周病治疗的辅助手段：一种创新方法。
Medicina (Kaunas). 2025 Jan 14;61(1):126. doi: 10.3390/medicina61010126.
本文引用的文献
1
NLRP3 inflammasome activity and periodontal disease pathogenesis-A bidirectional relationship.NLRP3 炎性小体活性与牙周病发病机制：双向关系。
Oral Dis. 2024 Oct;30(7):4069-4077. doi: 10.1111/odi.15005. Epub 2024 May 30.
2
Mechanistic insights into the role of probiotics in modulating immune cells in ulcerative colitis.探究益生菌在溃疡性结肠炎中调节免疫细胞作用的机制。
Immun Inflamm Dis. 2023 Oct;11(10):e1045. doi: 10.1002/iid3.1045.
3
Prevention and Health Benefits of Prebiotics, Probiotics and Postbiotics in Acute Lymphoblastic Leukemia.益生元、益生菌和后生元在急性淋巴细胞白血病中的预防作用及健康益处
Microorganisms. 2023 Jul 8;11(7):1775. doi: 10.3390/microorganisms11071775.
4
Prophylactic vs. Therapeutic Effect of Probiotics on the Inflammation Mediated by the NF-κB Pathway in Inflammatory Bowel Conditions.益生菌对炎症性肠病中由NF-κB途径介导的炎症的预防作用与治疗作用
Biomedicines. 2023 Jun 9;11(6):1675. doi: 10.3390/biomedicines11061675.
5
Association between different dietary patterns and eating disorders and periodontal diseases.不同饮食模式与饮食失调及牙周疾病之间的关联。
Front Oral Health. 2023 Mar 22;4:1152031. doi: 10.3389/froh.2023.1152031. eCollection 2023.
6
Clinical, microbiological and immunological short, medium and long-term effects of different strains of probiotics as an adjunct to non-surgical periodontal therapy in patients with periodontitis. Systematic review with meta-analysis.不同菌株益生菌作为牙周炎患者非手术牙周治疗辅助手段的临床、微生物学及免疫学短期、中期和长期效果。系统评价与荟萃分析
Jpn Dent Sci Rev. 2023 Dec;59:62-103. doi: 10.1016/j.jdsr.2023.02.001. Epub 2023 Mar 4.
7
Probiotic adjuvant treatment in combination with scaling and root planing in chronic periodontitis: a systematic review and meta-analysis.益生菌辅助治疗联合龈下刮治和根面平整术用于慢性牙周炎：一项系统评价与Meta分析
Benef Microbes. 2023 Apr 18;14(2):95-108. doi: 10.3920/BM2022.0056. Epub 2023 Mar 1.
8
The role of potential probiotic strains in various intestinal diseases: New roles for an old player.潜在益生菌菌株在各种肠道疾病中的作用：老角色的新作用。
Front Microbiol. 2023 Feb 2;14:1095555. doi: 10.3389/fmicb.2023.1095555. eCollection 2023.
9
Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health.益生菌对免疫细胞的作用机制及其对人类健康的有益影响。
Cells. 2023 Jan 2;12(1):184. doi: 10.3390/cells12010184.
10
Selfie Dental Plaque Index: A New Tool for Dental Plaque Assessment.自拍式牙菌斑指数：一种用于牙菌斑评估的新工具。
J Clin Exp Dent. 2022 Nov 1;14(11):e926-e931. doi: 10.4317/jced.59908. eCollection 2022 Nov.
Zotero 插件