Barz Andreas, Berger Joshua, Speicher Marco, Morsch Arne, Wanjek Markus, Rissland Jürgen, Jäger Johannes
German University for Prevention and Health Management, Saarbruecken, Germany.
Institute of Virology, Saarland University Medical Centre, Homburg, Germany.
Sci Rep. 2024 Dec 16;14(1):30511. doi: 10.1038/s41598-024-82584-4.
Fatigue is the most prevalent symptom within the post-COVID condition (PCC). Furthermore, many patients suffer from decreased physical performance capacity and post-exertional malaise. Although exercise has been proposed as an effective therapeutic strategy for PCC, there is limited evidence on individualised and symptom-titrated exercise interventions in patients with fatigue and PEM. Therefore, we conducted a multi-centre randomised controlled trial to investigate the effectiveness of an individualised and symptom-titrated exercise program. We measured fatigue, health-related quality of life, hand-grip strength, endurance capacity and PEM before and after the 10-week intervention. A total of 118 individuals with PCC were included in the final intention-to-treat analysis. All tests and training sessions took place in commercial fitness and health facilities. We found significant effects on fatigue severity, health-related quality of life and physical performance capacity. Adjusting the individual exercise load to daily fatigue has proven to be an effective and safe strategy in PCC patients with fatigue. Under the guidance of qualified professionals and by utilising symptom-titrated training recommendations, commercial fitness and health facilities present an appropriate setting for outpatient exercise rehabilitation in PCC.
疲劳是新冠后状况（PCC）中最普遍的症状。此外，许多患者存在身体机能下降和运动后不适的情况。尽管运动已被提议作为PCC的一种有效治疗策略，但关于针对疲劳和运动后不适患者的个性化及症状调整运动干预的证据有限。因此，我们开展了一项多中心随机对照试验，以研究个性化及症状调整运动方案的有效性。我们在为期10周的干预前后测量了疲劳、健康相关生活质量、握力、耐力和运动后不适。最终的意向性分析纳入了总共118名PCC患者。所有测试和训练课程均在商业健身和健康设施中进行。我们发现该方案对疲劳严重程度、健康相关生活质量和身体机能产生了显著影响。事实证明，根据每日疲劳程度调整个人运动负荷，对于患有疲劳的PCC患者来说是一种有效且安全的策略。在合格专业人员的指导下，通过采用症状调整训练建议，商业健身和健康设施为PCC患者的门诊运动康复提供了合适的场所。
