靶向肺癌中与癌症相关成纤维细胞表型相关的表观遗传改变
Targeting Epigenetic Alterations Linked to Cancer-Associated Fibroblast Phenotypes in Lung Cancer.
作者信息
Papavassiliou Kostas A, Sofianidi Amalia A, Gogou Vassiliki A, Papavassiliou Athanasios G
机构信息
First University Department of Respiratory Medicine, 'Sotiria' Chest Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
出版信息
Cancers (Basel). 2024 Nov 27;16(23):3976. doi: 10.3390/cancers16233976.
Abstract
The focus in cancer research and treatment has recently shifted from being primarily tumor-centric to emphasizing the tumor microenvironment (TME) [...].
摘要
癌症研究与治疗的重点最近已从主要以肿瘤为中心转向强调肿瘤微环境（TME）[...]。
相似文献
1
Targeting Epigenetic Alterations Linked to Cancer-Associated Fibroblast Phenotypes in Lung Cancer.靶向肺癌中与癌症相关成纤维细胞表型相关的表观遗传改变
Cancers (Basel). 2024 Nov 27;16(23):3976. doi: 10.3390/cancers16233976.
2
Intimate communications within the tumor microenvironment: stromal factors function as an orchestra.肿瘤微环境中的亲密通讯：基质因素作为一个管弦乐队发挥作用。
J Biomed Sci. 2023 Jan 4;30(1):1. doi: 10.1186/s12929-022-00894-z.
3
Epigenetic regulation and therapeutic targets in the tumor microenvironment.肿瘤微环境中的表观遗传调控与治疗靶点
Mol Biomed. 2023 Jun 5;4(1):17. doi: 10.1186/s43556-023-00126-2.
4
Strategy of targeting the tumor microenvironment via inhibition of fibroblast/fibrosis remodeling new era to cancer chemo-immunotherapy resistance.通过抑制成纤维细胞/纤维化重塑来靶向肿瘤微环境：癌症化疗免疫治疗耐药的新时代策略。
Eur J Pharmacol. 2023 Oct 15;957:175991. doi: 10.1016/j.ejphar.2023.175991. Epub 2023 Aug 22.
5
Tumor microenvironment: recent advances in understanding and its role in modulating cancer therapies.肿瘤微环境：理解方面的最新进展及其在调节癌症治疗中的作用
Med Oncol. 2025 Mar 18;42(4):117. doi: 10.1007/s12032-025-02641-4.
6
Epigenetic Modifications in Tumor-Associated Macrophages: A New Perspective for an Old Foe.肿瘤相关巨噬细胞中的表观遗传修饰：老对手的新视角。
Front Immunol. 2022 Jan 24;13:836223. doi: 10.3389/fimmu.2022.836223. eCollection 2022.
7
Cancer-Associated Fibroblasts in Conversation with Tumor Cells in Endometrial Cancers: A Partner in Crime.癌症相关成纤维细胞与子宫内膜癌肿瘤细胞的对话：共犯关系。
Int J Mol Sci. 2021 Aug 24;22(17):9121. doi: 10.3390/ijms22179121.
8
Inflammatory Components of the Thyroid Cancer Microenvironment: An Avenue for Identification of Novel Biomarkers.甲状腺癌微环境中的炎症成分：鉴定新型生物标志物的途径。
Adv Exp Med Biol. 2021;1350:1-31. doi: 10.1007/978-3-030-83282-7_1.
9
Epigenetic mechanisms driving tumor supportive microenvironment differentiation and function: a role in cancer therapy?驱动肿瘤支持性微环境分化和功能的表观遗传机制：在癌症治疗中发挥作用？
Epigenomics. 2020 Jan;12(2):157-169. doi: 10.2217/epi-2019-0165. Epub 2019 Dec 18.
10
Exploring lung cancer microenvironment: pathways and nanoparticle-based therapies.探索肺癌微环境：信号通路与基于纳米颗粒的疗法。
Discov Oncol. 2025 Feb 11;16(1):159. doi: 10.1007/s12672-025-01902-y.
本文引用的文献
1
Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials.定义肿瘤微环境中的癌症相关成纤维细胞（CAFs）：癌症免疫治疗的新机遇和临床试验的进展。
Mol Cancer. 2023 Oct 2;22(1):159. doi: 10.1186/s12943-023-01860-5.
2
Epigenetic regulation of cancer-associated fibroblast heterogeneity.癌症相关成纤维细胞异质性的表观遗传调控。
Biochim Biophys Acta Rev Cancer. 2023 May;1878(3):188901. doi: 10.1016/j.bbcan.2023.188901. Epub 2023 Apr 28.
3
Cancer-Associated Fibroblasts: Master Tumor Microenvironment Modifiers.癌症相关成纤维细胞：主要的肿瘤微环境调节因子
Cancers (Basel). 2023 Mar 22;15(6):1899. doi: 10.3390/cancers15061899.
4
LRRC3B and its promoter hypomethylation status predicts response to anti-PD-1 based immunotherapy.LRRC3B 及其启动子低甲基化状态可预测抗 PD-1 免疫治疗的反应。
Front Immunol. 2023 Jan 24;14:959868. doi: 10.3389/fimmu.2023.959868. eCollection 2023.
5
Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma.癌相关成纤维细胞特异性 lncRNA LINC01614 增强肺腺癌中的谷氨酰胺摄取。
J Hematol Oncol. 2022 Oct 8;15(1):141. doi: 10.1186/s13045-022-01359-4.
6
Self-carried nanodrug (SCND-SIS3): A targeted therapy for lung cancer with superior biocompatibility and immune boosting effects.自载纳米药物（SCND-SIS3）：一种具有优异生物相容性和免疫增强作用的肺癌靶向治疗药物。
Biomaterials. 2022 Sep;288:121730. doi: 10.1016/j.biomaterials.2022.121730. Epub 2022 Aug 12.
7
Cancer-associated fibroblasts in nonsmall cell lung cancer: From molecular mechanisms to clinical implications.非小细胞肺癌中的癌相关成纤维细胞：从分子机制到临床意义。
Int J Cancer. 2022 Oct 15;151(8):1195-1215. doi: 10.1002/ijc.34127. Epub 2022 Jun 8.
8
Hallmarks of Cancer: New Dimensions.癌症的特征：新视角。
Cancer Discov. 2022 Jan;12(1):31-46. doi: 10.1158/2159-8290.CD-21-1059.
9
Cancer-Associated Fibroblasts Facilitate Squamous Cell Carcinoma Lung Metastasis in Mice by Providing TGFβ-Mediated Cancer Stem Cell Niche.癌症相关成纤维细胞通过提供转化生长因子β介导的癌症干细胞微环境促进小鼠肺鳞状细胞癌转移。
Front Cell Dev Biol. 2021 Aug 30;9:668164. doi: 10.3389/fcell.2021.668164. eCollection 2021.
10
Epigenetic Reprogramming of Tumor-Associated Fibroblasts in Lung Cancer: Therapeutic Opportunities.肺癌中肿瘤相关成纤维细胞的表观遗传重编程：治疗机会
Cancers (Basel). 2021 Jul 27;13(15):3782. doi: 10.3390/cancers13153782.
Zotero 插件