Flouraki Eugenia, Loukopoulos Epameinondas, Gougoulis Dimitrios, Savvas Ioannis, Margeti Chrysoula, Karagianni Konstantina, Tsioli Vassiliki
Surgery Clinic, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.
Clinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.
Animals (Basel). 2024 Dec 5;14(23):3522. doi: 10.3390/ani14233522.
The administration of lidocaine as part of multimodal analgesia in dogs undergoing ovariohysterectomies demonstrates variable analgesic efficacy. The aim of this prospective, double-blinded clinical study was to evaluate the effectiveness of lidocaine 2% irrigation on the ovarian suspensory ligament, followed by localised massage, in achieving sufficient intraoperative analgesia. Thirty-eight female dogs were randomly divided to two groups and received either a splash block of 0.5 ml lidocaine 2% on each ovarian suspensory ligament (GL) or an equal volume of saline (GNS). All dogs were premedicated with dexmedetomidine (5 μg·kg) and buprenorphine (20 μg·kg) intramuscularly and meloxicam (0.2 mg·kg) subcutaneously. Anaesthesia was induced with propofol and maintained with isoflurane. The surgical procedure was initiated after an adequate depth of anaesthesia was achieved. Heart rate (HR), respiratory rate () and mean arterial pressure (MAP) were continuously monitored. Fentanyl (2 μg·kg) was administered as rescue analgesia in case of a 30% increase in HR, , or MAP, compared to their values before manipulation of the ovaries. Data were analysed using a mixed model for repeated measures ANOVA and Pearson's Chi-Square test. The need for rescue analgesia differed significantly between the two groups ( < 0.0005). In GNS, 89.47% (17/19) of the dogs required rescue analgesia, compared to 10.53% (2/19) of the dogs in GL. The relative risk of rescue for the GNS compared to the GL was approximately 8.5. In conclusion, intraoperative analgesia during ovariohysterectomies in dogs can be enhanced using a lidocaine 2% splash block combined with massage of the ovarian suspensory ligament.
利多卡因作为多模式镇痛的一部分用于接受卵巢子宫切除术的犬时，其镇痛效果存在差异。这项前瞻性、双盲临床研究的目的是评估2%利多卡因冲洗卵巢悬韧带并随后进行局部按摩在实现充分术中镇痛方面的有效性。38只雌性犬被随机分为两组，分别在每条卵巢悬韧带上接受0.5 ml 2%利多卡因的冲击阻滞（GL组）或等体积的生理盐水（GNS组）。所有犬均肌肉注射右美托咪定（5 μg·kg）和丁丙诺啡（20 μg·kg）并皮下注射美洛昔康（0.2 mg·kg）进行预处理。用丙泊酚诱导麻醉并用异氟烷维持。在达到足够的麻醉深度后开始手术。持续监测心率（HR）、呼吸频率（RR）和平均动脉压（MAP）。若HR、RR或MAP相较于卵巢操作前的值升高30%，则给予芬太尼（2 μg·kg）作为补救性镇痛。使用重复测量方差分析的混合模型和Pearson卡方检验对数据进行分析。两组之间补救性镇痛的需求存在显著差异（P < 0.0005）。在GNS组中, 89.47%（17/19）的犬需要补救性镇痛，而GL组中这一比例为10.53%（2/19）。与GL组相比，GNS组补救的相对风险约为8.5。总之，在犬卵巢子宫切除术中，使用2%利多卡因冲击阻滞并结合卵巢悬韧带按摩可增强术中镇痛效果。
