Sekelj Fures Jadranka, Duranovic Vlasta, Lenicek Krleza Jasna, Katusic Bojanac Ana, Loncar Lana, Dakovic Ivana, Pejic-Rosko Sanja, Vulin Katarina, Pilon-Far Andrijana, Simic Klaric Andrea
Department of Pediatric Neurology, Children's Hospital Zagreb, 10000 Zagreb, Croatia.
Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.
Diagnostics (Basel). 2024 Nov 24;14(23):2645. doi: 10.3390/diagnostics14232645.
Research on calcitonin-gene-related peptide (CGRP) in adult migraine is extensive, but its role in childhood migraine remains unclear. This study aimed to evaluate serum CGRP levels in children experiencing migraine and tension-type headache (TTH) during interictal periods, comparing these levels to age-matched healthy controls. A total of 66 migraine patients, 59 with TTH, and 53 controls were recruited and stratified by headache onset age: under 7, 7-12, and over 12 years. CGRP levels were quantified using enzyme-linked immunosorbent assay (ELISA). The migraine patients showed significantly higher serum CGRP levels than both the TTH patients and the controls ( < 0.001), with no significant difference between the latter two groups. Among the migraine patients, those without aura (MO) exhibited higher CGRP levels than those with aura (MA). The CGRP levels were lower in the. MA patients whose headaches began between ages 7 and 12 compared to the subjects with MO, while no significant differences were found in the patients whose headaches began after age 12. These findings suggest that elevated serum CGRP is indicative of pediatric migraine, with variations based on migraine type and age of onset. The difference in CGRP in preadolescent migraineurs with and without aura suggest that CGRP levels may vary depending on age and on migraine type.
降钙素基因相关肽（CGRP）在成人偏头痛中的研究广泛，但它在儿童偏头痛中的作用仍不清楚。本研究旨在评估偏头痛和紧张型头痛（TTH）儿童发作间期的血清CGRP水平，并将这些水平与年龄匹配的健康对照进行比较。共招募了66例偏头痛患者、59例TTH患者和53例对照，并按头痛发病年龄进行分层：7岁以下、7 - 12岁和12岁以上。使用酶联免疫吸附测定（ELISA）对CGRP水平进行定量。偏头痛患者的血清CGRP水平显著高于TTH患者和对照（<0.001），后两组之间无显著差异。在偏头痛患者中，无先兆偏头痛（MO）患者的CGRP水平高于有先兆偏头痛（MA）患者。与MO患者相比，头痛始于7至12岁的MA患者的CGRP水平较低，而头痛始于12岁以后的患者未发现显著差异。这些发现表明，血清CGRP升高提示儿童偏头痛，且因偏头痛类型和发病年龄而异。青春期前有先兆和无先兆偏头痛患者的CGRP差异表明，CGRP水平可能因年龄和偏头痛类型而异。
