Cohn Liel N, Bookstein Shai, Laytman Klein Tamar, Mordenfeld Kozlovsky Nadia, Ziv-Baran Tomer, Mayer Arnaldo, Katorza Eldad
Arrow Program for Medical Research Education, Chaim Sheba Medical Center, Tel-Hashomer 5262000, Israel.
School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Diagnostics (Basel). 2024 Nov 29;14(23):2700. doi: 10.3390/diagnostics14232700.
BACKGROUND/OBJECTIVES: Little is known about the advantages of Diffusion Tensor Imaging (DTI) when evaluating the fetal corpus callosum (CC), a sensitive indicator for normal brain development. This study evaluates the contribution of DTI compared to T2-weighted imaging to assess fetal CC biometry.
Data from the fetal MRI exams of singleton pregnancies between July 2017 and 2019 were retrospectively analyzed. Mid-sagittal sections were used to measure the CC biometry, and inter- and intra-observer agreements were assessed using the interclass correlation coefficient (ICC), targeting an ICC above 0.85.
The results from 100 patients (mean gestational age, 32.24 weeks) indicated excellent inter-observer reliability for DTI (ICC = 0.904, 95% CI = 0.815-0.952) and moderate agreement for T2-weighted imaging (ICC = 0.719, 95% CI = 0.556-0.842). Intra-observer assessments showed excellent reliability for both DTI and T2-weighted imaging (ICC = 0.967, 95% CI = 0.933-0.984 and ICC = 0.942, 95% CI = 0.884-0.971, respectively). However, a comparison between DTI and T2-weighted images for CC biometry showed poor agreement (ICC = 0.290, 95% CI = 0.071-0.476).
In conclusion, the study highlights a lack of agreement between DTI and T2-weighted imaging in fetal CC biometry, suggesting the need for further research to understand this discrepancy and the role of DTI in fetal health.
背景/目的：在评估胎儿胼胝体（CC）时，关于扩散张量成像（DTI）的优势鲜为人知，而CC是正常脑发育的一个敏感指标。本研究评估了DTI与T2加权成像相比在评估胎儿CC生物测量方面的作用。
回顾性分析2017年7月至2019年单胎妊娠胎儿MRI检查的数据。使用正中矢状面测量CC生物测量，并使用组内相关系数（ICC）评估观察者间和观察者内的一致性，目标是ICC高于0.85。
100例患者（平均孕周32.24周）的结果表明，DTI的观察者间可靠性极佳（ICC = 0.904，95%CI = 0.815 - 0.952），T2加权成像的一致性中等（ICC = 0.719，95%CI = 0.556 - 0.842）。观察者内评估显示DTI和T2加权成像的可靠性均极佳（ICC分别为0.967，95%CI = 0.933 - 0.984和ICC = 0.942，95%CI = 0.884 - 0.971）。然而，DTI与T2加权图像在CC生物测量方面的比较显示一致性较差（ICC = 0.290，95%CI = 0.071 - 0.476）。
总之，该研究突出了DTI与T2加权成像在胎儿CC生物测量方面缺乏一致性，表明需要进一步研究以了解这种差异以及DTI在胎儿健康中的作用。
