Department of Obstetrics, Fetal Medicine and Surgery, Necker-Enfants Malades Hospital, APHP, Paris, France.
EA Fetus 7328 and LUMIERE Platform, University of Paris, Paris, France.
Ultrasound Obstet Gynecol. 2023 Aug;62(2):175-184. doi: 10.1002/uog.26187.
Adequate reference ranges of size of the corpus callosum (CC) are necessary to improve characterization of CC abnormalities and parental counseling. The objective of this study was to evaluate the methodology used in studies developing references charts for CC biometry.
We conducted a systematic review of studies on fetal CC biometry using a set of predefined quality criteria of study design, statistical analysis and reporting methods. We included observational studies whose primary aim was to create ultrasound or magnetic resonance imaging charts for CC size in a normal population of fetuses. Studies were scored against a predefined set of independently agreed methodological criteria, and an overall quality score was given for each study.
Twelve studies met the inclusion criteria. Quality scores ranged between 17.4% and 95.7%. The greatest potential for bias was noted for the following items: sample selection and sample-size calculation, as only 17% of the studies were population-based and had consecutive or random recruitment of patients and with a justification of the sample size; number of measurements obtained for CC biometry, as only 17% of the studies performed more than one measurement per fetus and per scan; and description of characteristics of the study population, as only 8% of the studies clearly reported a minimum dataset of demographic characteristics.
Our review demonstrates substantial heterogeneity in methods and final biometric values of the fetal CC across the evaluated studies. The use of uniform methodology of the highest quality is essential in order to define a 'short' CC and provide appropriate parental counseling. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
充分的胼胝体（CC）大小参考范围对于改善 CC 异常的特征描述和家长咨询非常重要。本研究的目的是评估用于 CC 生物测量制定参考图表的研究中使用的方法。
我们使用一套预先设定的研究设计、统计分析和报告方法的质量标准，对胎儿 CC 生物测量的研究进行了系统回顾。我们纳入了主要目的是在正常胎儿群体中创建 CC 大小超声或磁共振成像图表的观察性研究。研究根据一组预先设定的独立达成的方法学标准进行评分，并为每项研究给出总体质量评分。
符合纳入标准的研究有 12 项。质量评分范围为 17.4%至 95.7%。以下项目存在最大的偏倚风险：样本选择和样本量计算，只有 17%的研究是基于人群的，对患者进行连续或随机招募，并对样本量进行了说明；CC 生物测量获得的测量次数，只有 17%的研究对每个胎儿和每次扫描进行了多次测量；以及研究人群特征的描述，只有 8%的研究清楚地报告了最小数据集的人口统计学特征。
我们的综述表明，评估研究中 CC 的方法和最终生物测量值存在很大的异质性。为了定义“短”CC 并提供适当的家长咨询，使用最高质量的统一方法至关重要。© 2023 作者。超声在妇产科由 John Wiley & Sons Ltd 代表国际妇产科超声学会出版。
