Saez-Carrion Ernesto, Aguilar-Aragon Mario, García-López Lucia, Dominguez Maria, Uribe Mary Luz
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Miguel Hernández (UMH), Campus de Sant Joan, 03550 Sant Joan d'Alacant, Spain.
Faculty of Health Sciences, Universidad Europea de Valencia, 03016 Alicante, Spain.
Cells. 2024 Nov 29;13(23):1977. doi: 10.3390/cells13231977.
Cancer is a multifactorial process involving genetic, epigenetic, physiological, and metabolic changes. The ability of tumours to regulate new reactive pathways is essential for their survival. A key aspect of this involves the decision-making process of cancer cells as they balance the exploitation of surrounding and distant tissues for their own benefit while avoiding the rapid destruction of the host. Nutrition plays a central role in these processes but is inherently limited. Understanding how tumour cells interact with non-tumoural tissues to acquire nutrients is crucial. In this review, we emphasise the utility of as a model organism for dissecting the complex oncogenic networks underlying these interactions. By studying various levels-from individual tumour cells to systemic markers-we can gain new insights into how cancer adapts and thrives. Moreover, developing innovative technologies, such as high-throughput methods and metabolic interventions, enhances our ability to explore how tumours adapt to different conditions. These technological advances allow us to explore tumour adaptations and open new opportunities for potential therapeutic strategies.
癌症是一个涉及基因、表观遗传、生理和代谢变化的多因素过程。肿瘤调节新反应途径的能力对其生存至关重要。这其中的一个关键方面涉及癌细胞的决策过程，即它们在平衡利用周围和远处组织以自身受益的同时，避免宿主的快速破坏。营养在这些过程中起着核心作用，但本质上是有限的。了解肿瘤细胞如何与非肿瘤组织相互作用以获取营养至关重要。在本综述中，我们强调了[具体内容缺失]作为一种模式生物在剖析这些相互作用背后复杂致癌网络方面的效用。通过研究从单个肿瘤细胞到全身标志物的各个层面，我们可以对癌症如何适应和发展获得新的见解。此外，开发创新技术，如高通量方法和代谢干预，增强了我们探索肿瘤如何适应不同条件的能力。这些技术进步使我们能够探索肿瘤适应性，并为潜在治疗策略开辟新机会。
