Liu Wenjie, Kovacs Antal H, Hou Jinqiang
Department of Chemistry, Lakehead University, 955 Oliver Rd, Thunder Bay, ON P7B 5E1, Canada.
Thunder Bay Regional Health Research Institute, 980 Oliver Road, Thunder Bay, ON P7B 6V4, Canada.
Cells. 2024 Dec 6;13(23):2022. doi: 10.3390/cells13232022.
Cancer cell dormancy is a critical phase in cancer development, wherein cancer cells exist in a latent state marked by temporary but reversible growth arrest. This dormancy phase contributes to anticancer drug resistance, cancer recurrence, and metastasis. Treatment strategies aimed at cancer dormancy can be categorized into two contradictory approaches: inducing cancer cells into a dormant state or eliminating dormant cells. While the former seeks to establish permanent dormancy, the latter aims at eradicating this small population of dormant cells. In this review, we explore the current advancements in therapeutic methods targeting cancer cell dormancy and discuss future strategies. The concept of cancer cell dormancy has emerged as a promising avenue for novel cancer treatments, holding the potential for breakthroughs in the future.
癌细胞休眠是癌症发展中的一个关键阶段，在此阶段癌细胞以暂时但可逆的生长停滞为特征处于潜伏状态。这个休眠阶段会导致抗癌药物耐药性、癌症复发和转移。针对癌细胞休眠的治疗策略可分为两种相互矛盾的方法：诱导癌细胞进入休眠状态或消除休眠细胞。前者试图建立永久性休眠，而后者旨在根除这一小部分休眠细胞。在这篇综述中，我们探讨了针对癌细胞休眠的治疗方法的当前进展，并讨论了未来的策略。癌细胞休眠的概念已成为新型癌症治疗的一个有前景的途径，未来有可能取得突破。
