González-Manzano Susana, Ayuda-Durán Begoña, Martín-Sanz Roberto, Garzón-García Lidia, Santos-Buelga Celestino, González-Paramás Ana María
Grupo de Investigación en Polifenoles (GIP-USAL), Unidad de Nutrición y Bromatología, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.
Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
Foods. 2024 Nov 29;13(23):3865. doi: 10.3390/foods13233865.
Alzheimer's disease (AD), a major neurodegenerative disorder, is characterized by the progressive accumulation of amyloid-β (Aβ) plaques, leading to cognitive decline. Despite the existing treatments, their limited efficacy highlights the urgent need for novel therapeutic strategies. The present study investigates the neuroprotective effects of a grape seed polyphenol extract (GSPE) on transgenic models specifically expressing human Aβ proteins. The obtained results show that GSPE not only significantly attenuates Aβ-induced paralysis but also extends the lifespan and improves sensory responses in these models, suggesting improved neural function and overall health. Additionally, GSPE treatment reduces proteasomal activity, which could lead to a reduction in the accumulation of misfolded proteins. It also modulates the expression of key genes involved in autophagy and proteostasis, thereby enhancing cellular mechanisms to manage protein aggregation and combat oxidative stress. On the whole, these findings support the potential of grape seed procyanidins (the main components in the extract) to be used as an effective dietary approach to mitigate Alzheimer's disease pathology through the modulation of critical neuroprotective pathways.
阿尔茨海默病（AD）是一种主要的神经退行性疾病，其特征是β-淀粉样蛋白（Aβ）斑块的逐渐积累，导致认知能力下降。尽管现有治疗方法存在，但它们有限的疗效凸显了对新型治疗策略的迫切需求。本研究调查了葡萄籽多酚提取物（GSPE）对特异性表达人Aβ蛋白的转基因模型的神经保护作用。所得结果表明，GSPE不仅能显著减轻Aβ诱导的麻痹，还能延长这些模型的寿命并改善感觉反应，表明神经功能和整体健康状况得到改善。此外，GSPE处理降低了蛋白酶体活性，这可能导致错误折叠蛋白积累的减少。它还调节参与自噬和蛋白质稳态的关键基因的表达，从而增强细胞机制以管理蛋白质聚集并对抗氧化应激。总体而言，这些发现支持葡萄籽原花青素（提取物中的主要成分）通过调节关键的神经保护途径，作为减轻阿尔茨海默病病理的有效饮食方法的潜力。
