Cho Hye-Sun, Koh Jueun, Yim Gyeonghye, Jang Hongje, Kim Young-Kwan
Department of Chemistry, Dongguk University-Seoul Campus, 30 Pildong-ro 1-gil, Jung-gu, Seoul 04620, Republic of Korea.
Department of Chemistry, Kwangwoon University, 20 Gwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea.
Nanomaterials (Basel). 2024 Dec 4;14(23):1946. doi: 10.3390/nano14231946.
The core@shell nanostars composed of star-like Au nanocores with TiO shells (Au@TiO NSs) are synthesized in a one-pot reaction without any reducing or surface-controlling agents. The Au@TiO NSs exhibit strong absorption in the UV region based on the interaction between the Au nanocore and the TiO shell, and this optochemical property leads to the efficient laser desorption/ionization time-of-flight mass spectrometry (LDI-TOF-MS) analysis of small molecules with low background interference and high reproducible mass signals compared with spherical Au nanoparticles (NPs). The limit of detection and dynamic range values of various analytes also improved with Au@TiO NSs compared with those obtained with spherical Au NPs. Our findings successfully demonstrate that Au@TiO NSs are a promising matrix for the LDI-TOF-MS analysis of various small molecules as well as synthetic polymers.
由具有TiO壳层的星状金纳米核组成的核@壳纳米星（Au@TiO NSs）在一锅反应中合成，无需任何还原剂或表面控制剂。基于金纳米核与TiO壳层之间的相互作用，Au@TiO NSs在紫外区域表现出强烈吸收，与球形金纳米颗粒（NPs）相比，这种光化学性质导致小分子的高效激光解吸/电离飞行时间质谱（LDI-TOF-MS）分析具有低背景干扰和高重现性的质量信号。与球形金纳米颗粒相比，Au@TiO NSs对各种分析物的检测限和动态范围值也有所提高。我们的研究结果成功证明，Au@TiO NSs是用于各种小分子以及合成聚合物的LDI-TOF-MS分析的有前途的基质。
