Jayeoye Titilope John, Panghiyangani Roselina, Singh Sudarshan, Muangsin Nongnuj
Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Biomedic, Faculty of Medicine, Universitas Lambung Mangkurat, Kota Banjarmasin 70123, Indonesia.
Nanomaterials (Basel). 2024 Dec 7;14(23):1967. doi: 10.3390/nano14231967.
In this contribution, facile synthesis of gold nanoparticles (AuNPs) at ambient conditions is reported based on the use of the polyphenolic compound quercetin (QT) as the reducing and stabilizing agent at room temperature (RT). Under alkali-induced pH adjustment of QT solution and stirring conditions at RT, QT could quickly reduce gold salt (Au) into its nanoparticle form (Au), resulting in the formation of a sparkling red color colloidal solution (AuNPs) with an absorption maximum at 520 nm. Further, Fourier transform infrared spectroscopy (FTIR) was employed to showcase the role of QT in the nanomaterial's synthesis process. The formed QT-AuNPs responded swiftly to Al charging with color perturbation from red to grayish-purple, coupled with an absorption spectra red shift, owing to Al-induced aggregation of QT-AuNPs. However, when fluoride ion (F) was pre-mixed with an optimized Al concentration, reversed color changes from grayish-purple to red were observed with a blue shift in the absorption spectra. Simply put, F formed a complex with Al, thus preventing Al-induced aggregation of QT-AuNPs. The analytical response A/A was linear with F concentration ranging from 25.0 to 250.0 µM and 250.0-600.0 µM, with a detection limit of 7.5 µM. The developed QT-AuNPs/Al detection probe was selective to only F charging, in comparison with other possible interfering anions. Real sample potentiality of the developed sensor was demonstrated on tap water samples, toothpaste, and fluoride-rich mouthwash, with reliable accuracy.
在本论文中，报道了在室温环境下基于使用多酚化合物槲皮素（QT）作为还原和稳定剂来简便合成金纳米颗粒（AuNPs）。在碱诱导的QT溶液pH调节及室温搅拌条件下，QT能迅速将金盐（Au）还原为纳米颗粒形式（Au），从而形成在520 nm处有最大吸收的亮红色胶体溶液（AuNPs）。此外，采用傅里叶变换红外光谱（FTIR）来展示QT在纳米材料合成过程中的作用。所形成的QT-AuNPs对铝离子（Al）的加入反应迅速，颜色从红色变为灰紫色，同时吸收光谱发生红移，这是由于Al诱导的QT-AuNPs聚集所致。然而，当氟离子（F）与优化后的Al浓度预混合时，观察到颜色从灰紫色变为红色的反向变化，且吸收光谱发生蓝移。简而言之，F与Al形成了络合物，从而防止了Al诱导的QT-AuNPs聚集。分析响应A/A与F浓度在25.0至250.0 μM以及250.0 - 600.0 μM范围内呈线性关系，检测限为7.5 μM。与其他可能的干扰阴离子相比，所开发的QT-AuNPs/Al检测探针仅对F的加入具有选择性。所开发传感器在自来水样品、牙膏和富含氟化物的漱口水上展示了实际样品潜力，具有可靠的准确性。
