Kapper Celine, Stelzl Patrick, Oppelt Peter, Ganhör Clara, Gyunesh Ayberk Alp, Arbeithuber Barbara, Rezk-Füreder Marlene
Experimental Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria.
Department for Gynaecology, Obstetrics and Gynaecological Endocrinology, Kepler University Hospital, Johannes Kepler University Linz, 4020 Linz, Austria.
Nutrients. 2024 Nov 27;16(23):4068. doi: 10.3390/nu16234068.
Female fertility and reproductive system disorders are influenced by a complex interplay of biological, physiological, and environmental factors. Minerals have emerged as crucial yet often overlooked elements that impact fertility and the prevalence of reproductive system disorders.
BACKGROUND/OBJECTIVES: This review aims to provide a comprehensive overview of the multifaceted role of minerals in female fertility, focusing on key areas such as oocyte quality, ovulation, embryo development, oxidative stress, miscarriage, hormonal regulation, environmental exposure, and in-vitro fertilization (IVF) outcomes.
A systematic review was conducted, focusing on randomized controlled trials (RCTs), prospective cohort studies, case-control studies, nested case-control, and observational studies examining mineral supplementation and nutrition in women planning pregnancy or utilizing assisted reproduction technologies (ARTs). Relevant literature was sourced from multiple electronic databases, including PubMed, Scopus, Google Scholar, Web of Science, and the Cochrane Library, using keywords related to minerals and female fertility. The quality of studies was assessed using the Newcastle-Ottawa Scale (NCO) for non-randomized studies and the Risk of Bias (RoB) tool for RCTs. This systematic review has been registered on PROSPERO (registration number is CDR 42024547656).
From an initial pool of 20,830 records, 39 articles met the inclusion criteria and were analyzed. The studies addressed various reproductive outcomes influenced by minerals: embryo development, oocyte quality, oxidative stress, miscarriage, hormonal regulation, IVF outcomes, environmental exposure, and minerals as biomarkers. The analysis revealed that minerals like selenium, zinc, and copper are essential for maintaining reproductive health, while exposure to toxic metals such as cadmium and lead is detrimental.
This review highlights the crucial role of both mineral supplementation and serum mineral status in female fertility. The findings provide key insights for clinicians to improve reproductive health through targeted mineral intake and monitoring. Further research is needed to refine guidelines for supplementation and serum levels in women with fertility issues.
女性生育能力和生殖系统疾病受到生物、生理和环境因素复杂相互作用的影响。矿物质已成为影响生育能力和生殖系统疾病患病率的关键但常常被忽视的因素。
背景/目的：本综述旨在全面概述矿物质在女性生育能力中的多方面作用，重点关注卵母细胞质量、排卵、胚胎发育、氧化应激、流产、激素调节、环境暴露和体外受精（IVF）结果等关键领域。
进行了一项系统综述，重点关注随机对照试验（RCT）、前瞻性队列研究、病例对照研究、巢式病例对照研究以及观察性研究，这些研究考察了计划怀孕或使用辅助生殖技术（ART）的女性的矿物质补充和营养情况。使用与矿物质和女性生育能力相关的关键词，从多个电子数据库中获取相关文献，包括PubMed、Scopus、谷歌学术、科学网和考克兰图书馆。使用纽卡斯尔-渥太华量表（NCO）评估非随机研究的质量，使用随机对照试验的偏倚风险（RoB）工具评估随机对照试验的质量。本系统综述已在PROSPERO上注册（注册号为CDR 42024547656）。
从最初的20830条记录中，有39篇文章符合纳入标准并进行了分析。这些研究涉及矿物质影响的各种生殖结果：胚胎发育、卵母细胞质量、氧化应激、流产、激素调节、IVF结果、环境暴露以及矿物质作为生物标志物。分析表明，硒、锌和铜等矿物质对维持生殖健康至关重要，而接触镉和铅等有毒金属则有害。
本综述强调了矿物质补充和血清矿物质状态在女性生育能力中的关键作用。这些发现为临床医生通过有针对性的矿物质摄入和监测来改善生殖健康提供了关键见解。需要进一步研究以完善针对有生育问题女性的补充指南和血清水平标准。
