Mokgalaboni Kabelo, Mashaba Reneilwe G, Phoswa Wendy N, Lebelo Sogolo L
Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, Florida Campus, Roodepoort 1709, South Africa.
DIMAMO Population Health Research Centre, University of Limpopo, Sovenga, Private Bag X1106, Polokwane 0727, South Africa.
Nutrients. 2024 Nov 30;16(23):4177. doi: 10.3390/nu16234177.
Controlling hyperglycemia and inflammation in type 2 diabetes (T2D) remains an important approach to control diabetes. The use of phytochemicals found in natural herbs has been investigated widely, and there are inconsistent findings in clinical trials, likely associated with a small sample size. A meta-analysis of clinical trials was performed by conducting a comprehensive literature search on PubMed, Scopus, EBSCOHost, and Web of Sciences. The search terms included , turmeric, curcumin, curcuma xanthorrhiza, diferuloylmethane, and type 2 diabetes. Data were analyzed using an online meta-analysis tool, Jamovi version 2.4.8 and IBM SPSS statistics version 29. The data were reported as either mean difference (MD) or standard mean difference (SMD) and 95% confidence intervals. The evidence from 18 trials with 1382 T2D with a mean age of 55.9 years was analyzed. Supplementation with curcumin led to a significant decrease in fasting blood glucose, MD = -11.48 mg/dL, 95%CI (-14.26, -8.70), < 0.01 and glycated hemoglobin, MD = -0.54%, 95%CI (-0.73, -0.35), < 0.01. Additionally, there was a significant decrease in C-Reactive Protein in curcumin compared to a placebo, SMD = -0.59, 95%CI (-1.11, -0.07), = 0.03. The findings observed in this study suggest that curcumin can ameliorate hyperglycemia and inflammation in T2D compared to a placebo. While the potential benefits were observed, it is recommended that future trials focus on finding a suitable dose and duration of intervention and incorporate formulation in curcumin to enhance its absorption.
控制2型糖尿病（T2D）中的高血糖和炎症仍然是控制糖尿病的重要方法。天然草药中发现的植物化学物质的使用已得到广泛研究，但临床试验结果并不一致，这可能与样本量较小有关。通过对PubMed、Scopus、EBSCOHost和Web of Sciences进行全面的文献检索，对临床试验进行了荟萃分析。检索词包括姜黄、姜黄素、郁金、二阿魏酰甲烷和2型糖尿病。使用在线荟萃分析工具Jamovi 2.4.8版和IBM SPSS Statistics 29版对数据进行分析。数据报告为平均差（MD）或标准化平均差（SMD）以及95%置信区间。分析了来自18项试验的证据，这些试验涉及1382名平均年龄为55.9岁的2型糖尿病患者。补充姜黄素导致空腹血糖显著降低，MD = -11.48 mg/dL，95%CI（-14.26，-8.70），P < 0.01，糖化血红蛋白也显著降低，MD = -0.54%，95%CI（-0.73，-0.35），P < 0.01。此外，与安慰剂相比，姜黄素组的C反应蛋白显著降低，SMD = -0.59，95%CI（-1.11，-0.07），P = 0.03。本研究观察到的结果表明，与安慰剂相比，姜黄素可改善2型糖尿病患者的高血糖和炎症。虽然观察到了潜在益处，但建议未来的试验集中于找到合适的干预剂量和持续时间，并将姜黄素制剂纳入其中以提高其吸收率。
