Febriza Ami, Zahrah Anisah Ainun, Andini Nurul Sulfi, Usman Fityatun, Idrus Hasta Handayani
Department of Physiology, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Makassar, Makassar, South Sulawesi, Indonesia.
Centre for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Centre, Bogor, West Java, Indonesia.
Diabetes Metab Syndr Obes. 2024 Sep 4;17:3305-3313. doi: 10.2147/DMSO.S468059. eCollection 2024.
The prevalence of diabetes mellitus has significantly increased, with 537 million individuals living with diabetes in 2021. Curcumin, a natural compound present in turmeric, has anti-inflammatory and antioxidant properties that aid in controlling diabetes. Curcumin can lower blood glucose levels, increase pancreatic cell function, and reduce insulin resistance. The pathophysiology of diabetes involves oxidative stress and endoplasmic reticulum stress, which can lead to cell death. This study aimed to evaluate the antidiabetic activity of curcumin in rats by administering it for a month and evaluating pancreatic tissue histology.
STZ-induced diabetic rats were fed a high-fat diet containing glibenclamide, 200 mg/kg body weight (BW) curcumin, 400 mg/kg BW curcumin, or a placebo for 4 weeks. After intervention, blood glucose levels were measured, and the pancreatic tissue was examined. Blood glucose levels were measured at 0, 2, 4, 6, and 8 h.
One-way ANOVA was performed to measure the mean difference among the groups at 0, 2, 4, 6, and 8 h of observation, which reported a statistically significant difference (p < 0.05). The blood glucose levels decreased after 4 h in the group receiving curcumin. Histological evaluation of the pancreas showed slight hydropic degeneration after 4 weeks of curcumin treatment.
Our study indicates that curcumin has a beneficial effect in diabetic rats by reducing blood glucose levels and a protective effect on the pancreas.
糖尿病的患病率显著增加，2021年有5.37亿人患有糖尿病。姜黄素是姜黄中的一种天然化合物，具有抗炎和抗氧化特性，有助于控制糖尿病。姜黄素可降低血糖水平，增强胰腺细胞功能，并降低胰岛素抵抗。糖尿病的病理生理学涉及氧化应激和内质网应激，这可能导致细胞死亡。本研究旨在通过给大鼠服用姜黄素一个月并评估胰腺组织组织学来评价姜黄素的抗糖尿病活性。
将链脲佐菌素诱导的糖尿病大鼠喂以含有格列本脲、200毫克/千克体重姜黄素、400毫克/千克体重姜黄素或安慰剂的高脂饮食，持续4周。干预后，测量血糖水平，并检查胰腺组织。在0、2、4、6和8小时测量血糖水平。
进行单因素方差分析以测量观察0、2、4、6和8小时时各组之间的平均差异，结果显示差异具有统计学意义（p<0.05）。接受姜黄素治疗的组在4小时后血糖水平下降。姜黄素治疗4周后胰腺的组织学评估显示有轻微的水样变性。
我们的研究表明，姜黄素对糖尿病大鼠具有降低血糖水平的有益作用，并对胰腺具有保护作用。
