Hasan Sarah Ahmed, Khaleel Abbas, Hisaindee Soleiman, Meetani Mohammed A
Chemistry Department, College of Science, United Arab Emirates University, Al-Ain P.O. Box 15551, United Arab Emirates.
Molecules. 2024 Dec 5;29(23):5752. doi: 10.3390/molecules29235752.
The presence of drugs in wastewater effluent is of concern due to their effects on the aquatic fauna and flora and there are growing efforts for their removal from the environment. In this paper, we study the photocatalytic visible-light degradation of naproxen, an over-the-counter anti-inflammatory drug, using 5% copper-doped TiO. The photocatalyst was characterized by XRD and BET surface area measurements. The optimal conditions for the degradation of 1 × 10 M of naproxen were found to be 3 h, with a catalyst loading of 50 mg/100 mL of the drug solution, and an acidic pH of 4.55. The degradation followed pseudo-first order kinetics and achieved a photodegradation efficiency of 44.8%. HPLC was used to separate the degradation products and their structures were determined using MS/MS data. A pathway for the degradation of naproxen is proposed along with degradation mechanisms. The major degradation events involve the formation of hydroxyl radicals, hydroxylation, keto-enol tautomerism, and decarboxylation.
废水中药物的存在因其对水生动植物的影响而受到关注，并且人们越来越努力从环境中去除这些药物。在本文中，我们研究了使用5%铜掺杂二氧化钛对非处方抗炎药萘普生进行光催化可见光降解。通过XRD和BET表面积测量对光催化剂进行了表征。发现降解1×10⁻⁵ M萘普生的最佳条件为3小时，催化剂负载量为50 mg/100 mL药物溶液，酸性pH值为4.55。降解遵循准一级动力学，光降解效率达到44.8%。使用HPLC分离降解产物，并利用MS/MS数据确定其结构。提出了萘普生的降解途径以及降解机制。主要降解过程包括羟基自由基的形成、羟基化、酮-烯醇互变异构和脱羧反应。
