Studzińska-Sroka Elżbieta, Paczkowska-Walendowska Magdalena, Kledzik Justyna, Galanty Agnieszka, Gościniak Anna, Szulc Piotr, Korybalska Katarzyna, Cielecka-Piontek Judyta
Department of Pharmacognosy and Biomaterials, Poznań University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
Department of Pharmacognosy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Molecules. 2024 Dec 6;29(23):5775. doi: 10.3390/molecules29235775.
Black elderberry ( L.) flowers are rich in polyphenolic compounds, including chlorogenic acid and quercetin derivatives, which are known for their health benefits, particularly their antioxidant and antidiabetic properties. This study aimed to optimize the extraction conditions using the Box-Behnken model to maximize polyphenol yields from different elderberry flower cultivars and to evaluate their potential for antidiabetic action. The extracts were analyzed for their phytochemical content and assessed for enzyme inhibition, specifically targeting enzymes critical in carbohydrate digestion and glucose regulation. The anti-inflammatory activity was also assessed. Results indicated that the Black Beauty, Obelisk, and Haschberg cultivars demonstrated significant inhibition of α-glucosidase, with a high inhibitory potential against α-amylase enzymes for the Obelisk cultivar. Additionally, high chlorogenic acid content was strongly correlated with enzyme inhibition and antioxidant activity, suggesting its substantial role in glucose regulation. This study underscores the potential of elderberry flower extracts, particularly those rich in chlorogenic acid, as natural agents for managing blood glucose levels, warranting further exploration of their use in antidiabetic applications.
黑接骨木（L.）花富含多酚类化合物，包括绿原酸和槲皮素衍生物，这些化合物因其对健康有益而闻名，尤其是其抗氧化和抗糖尿病特性。本研究旨在使用Box-Behnken模型优化提取条件，以最大限度地提高不同接骨木花品种的多酚产量，并评估其抗糖尿病作用的潜力。对提取物的植物化学成分进行分析，并评估其酶抑制作用，特别针对碳水化合物消化和葡萄糖调节中起关键作用的酶。还评估了其抗炎活性。结果表明，“黑美人”、“方尖碑”和“哈施贝格”品种对α-葡萄糖苷酶有显著抑制作用，“方尖碑”品种对α-淀粉酶具有很高的抑制潜力。此外，高绿原酸含量与酶抑制和抗氧化活性密切相关，表明其在葡萄糖调节中起重要作用。本研究强调了接骨木花提取物，特别是富含绿原酸的提取物，作为控制血糖水平的天然药物的潜力，值得进一步探索其在抗糖尿病应用中的用途。
